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Signal Transducer and Activator of Transcription 1 (STAT1) regulates energy metabolic pathways in tumors, predominantly via glycolytic genes, suggesting a role for STAT1 as a transcriptional modulator of genes involved in "Warburg effect" cancer cell energy production.
The antiproliferative effects of vitamin D on a breast tumour cell line persist despite knockdown of the vitamin D receptor gene, and variants resistant to these anti-proliferative effects do not show changes in known vitamin D signaling pathway genes.
Genetic pathways involving appetite, satiety and reward affect alcohol consumption in rats and humans, specifically GABAergic and dopaminergic signaling, but genes in these pathways are not linked to alcohol dependence or abuse in people.
The oxytocin signalling pathway and in particular, the genomic deletion or aberrant methylation of the oxytocin receptor gene may play a role in the development of autism.
Gene expression profiling of the microbial content of the periodontal pockets of patients with the inflammatory gum disease periodontitis, shows that colonization levels of several bacteria correlate with gene expression in the adjacent gum tissue.