Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster

Drosophila melanogaster fruit flies raised in a zero-gravity environment created by a superconducting magnet show substantial changes in the expression of many essential genes, suggesting that extended weightlessness during space flight could also potentially have negative effects on cellular processes.

DNA-protein interactions in high definition

Mendenhall and Bernstein highlight ChIP-exo, which is an elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors

Molecular prediction for atherogenic risks across different cell types of leukocytes

An new set of 56 gene expression biomarkers could be used to predict early atherosclerosis from leukocytes before the symptoms of heart disease have developed, and this test can be further refined to identify very high risk patients.

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients

miRNA profiles, obtained using multiple acquisition, data processing, and analysis methods, distinguished ES and uninfected controls from viremic HIV-1-infected patients. For several miRNAs, however, ES and viremic patients shared similar expression patterns. Differentially expressed miRNAs included those with reported roles in HIV-1 latency (miR-29 family members, miRs -125b and -150). Others, such as miR-31 and miR-31*, had no previously reported connection with HIV-1 infection but were found here to differ significantly with uncontrolled HIV-1 replication.

Guidelines for Information About Therapy Experiments: a proposal on best practice for recording experimental data on cancer therapy

As part of our thematic series, Richard Begent and colleagues present recommendations for creating an information checklist to provide a consistent framework for transparently reporting the results of therapeutic experiments.