Japan Gateway

Preventing NSAID induced injuries

Irsogladine provides better protection against NSAID-induced small-intestinal injuries than the PPI Omeprazole in healthy subjects assessed by biochemical approaches and capsule endoscopy, suggesting it could provide protection against NSAID-induced injuries to the entire digestive tract

A new platform for investigating Dravet syndrome

Induced pluripotent stem cells from the skin of patients with Dravet syndrome show Dravet-like functional impairment when they are converted into neurons, providing an unparalleled insight into the mechanism behind this rare form of infantile-onset epilepsy.

ADHD drug may alter neural stem cell activity

Methylphenidate, a drug commonly used to treat ADHD, enhances differentiation and inhibits proliferation of murine neural stem cells in vitro, further highlighting possible long-term effects of the drug on brain development.

Autoantibodies as targets for SLE

Takahisa Gono and colleagues comment on a study in mice in which 16/6 idiotype (Id) antibody impairs memory, and argue antibody cross-reactivity could explain the diverse clinical features in SLE with the autoantibody targets as potential therapies.

Microgravity aids spinal cord therapy

In a rat model of spinal cord injury, transplantation of rat bone marrow stromal cells cultured under simulated microgravity resulted in improved functional recovery compared to rats receiving cells cultured under standard gravity conditions.