Microbiology and Infectious Diseases Gateway
Welcome to BioMed Central's Microbiology and Infectious Diseases Gateway. This gateway highlights the latest articles we have published in the microbiology and infectious diseases fields.
A new vaccine for Rift Valley Fever, a disease of livestock and humans, was engineered from chimpanzee adenovirus and protected mice from infection, paving the way for clinical trials.
HIV-associated tuberculosis (HIV-TB) is the leading cause of death in HIV-infected individuals; Stephen Lawn and colleagues review diagnosis and treatment of HIV-TB in resource-limited settings, and discuss the challenges of managing drug-resistant TB.
In a simulation model, accidental laboratory escape of a genetically engineered influenza virus may not be detected, and containment of disease is not guaranteed, suggesting that adequate preparedness plans for virus escape are needed.
Life expectancy (LE) in HIV-positive individuals has increased with the use of antiretroviral therapy; Caroline Sabin reviews the factors affecting mortality rates and emphasizes that targeting lifestyle factors could further improve LE in these patients.
Screening for viruses in multiple cancer types from next generation sequencing data demonstrates a high presence of viral sequences with potential oncogenic roles in gastrointestinal adenocarcinomas.
Mark Wainberg and colleagues argue that as the HIV integrase inhibitor, Dolutegravir (DTG), does not select for resistance mutations when used in first-line therapy, it may potentially play a role in long-term treatment and management of HIV.
Influenza A virus was shown to cut through mucus to infect the underlying cells, by cleaving sialic acid with its neuraminidase protein, identifying a new way flu has evolved to disarm our defences.
Epstein-Barr Virus was found as a co-infection with Human Papilloma Virus in a proportion of cervical cancer cases in Algerian women, suggesting it may have a role in disease progression.
An unusual type of Human Papillomavirus, HPV58, was detected in oropharyngeal carcinoma of a 69-year-old woman, providing rare evidence for types other than HPV16 as a cause of this cancer.
Following initiation of highly active anti-retroviral therapy there is a significant association between low CCL3L1 gene copy number and improved immune reconstitution in patients, which is not seen prior to the start of drug treatment.
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