Gastroenterology Gateway

Definition of a pancreatic cancer subtype

Molecular and clinical characterization of HER2 amplification in pancreatic ductal adenocarcinoma reveals a distinct subtype, which can be detected by standardized assays.

Serogenetic tests estimate CD prevalence

A novel screening approach involving human leukocyte antigen (HLA)-DQ gene testing and confirmatory serology accurately estimates the prevalence of celiac disease (CD), and could help to reduce the number of unnecessary gastroscopies.

Clinical evidence for allergy in OFG

Allergy is more prevalent in patients with orofacial granulomatosis (OFG) than in the general population, providing evidence for allergic components in this condition, which could lead to improved individualized dietary treatments.

Frequent exacerbations in COPD

The frequent exacerbator phenotype is a distinct clinical subgroup in chronic obstructive pulmonary disease (COPD) patients; Jadwiga Wedzicha and colleagues review the pathophysiology of this phenotype and its interaction with other comorbidities.

MitoQ improves IBD symptoms

The antioxidant MitoQ improves colitis symptoms and reduces inflammation in a mouse model of inflammatory bowel disease (IBD), suggesting that MitoQ could represent a new therapeutic agent for the treatment of acute IBD.