Emerging patterns of genetic overlap across autoimmune disorders

Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.

Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells

Luteolin, a flavonoid found in fruits and vegetables, reduces insulin-like growth factor-I receptor (IGF-IR) signaling in colon cancer cells, suggesting that this mechanism may contribute to luteolin-induced apoptosis and cell cycle arrest.

Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation

Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.

Th17-related cytokines: new players in the control of chronic intestinal inflammation

Monteleone and colleagues review the evidence of how T helper 17 (Th17) cells and the cytokines they produce contribute to inflammatory bowel diseases (IBD) and discuss how this knowledge contributes to new avenues of therapeutic development for these diseases.

Delay to celiac disease diagnosis and its implications for health-related quality of life

Treatment of celiac disease significantly improves health-related quality of life, however long delays often occur between the development of symptoms and diagnosis of the diease, mass screening may improve the time to diagnosis.