Gastroenterology Gateway

Anti-CD137-mediated inhibition of EG7 lymphoma

T cells use both perforin/granzyme and FasL mechanisms to achieve tumor inhibition following treatment of mice with anti-CD137 suggesting that they are promising therapeutic agents for cancer treatment

Rethinking developmental methylation

A Research Highlight examines why differentiation in the small intestine crypt bypasses the DNA methylation changes observed in other lineage progressions

Less painful CT colonography

Administration of an intravenous alfentanil bolus before CT colonography significantly reduces pain during colonic insufflation compared to administration of a placebo and could improve acceptance of CT colonography for colorectal cancer screening

Comparative outcomes in Crohn?s disease surgery

Meta-analyses of trials with both randomised and non-randomised designs indicates a lower risk of perioperative complications and incisional hernias when laparoscopic resection is performed for Crohn’s disease compared to open resection, but no evidence of other differences.

Preventing NSAID induced injuries

Irsogladine provides better protection against NSAID-induced small-intestinal injuries than the PPI Omeprazole in healthy subjects assessed by biochemical approaches and capsule endoscopy, suggesting it could provide protection against NSAID-induced injuries to the entire digestive tract