Diabetes Gateway

Biological dysregulation in depression

Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.

Monitoring neurodegeneration in diabetes

Adult neural stem cells extracted from the olfactory bulb of diabetic rats can be cultured in vitro and show similar gene expression profiles to hippocampal neural stem cells during diabetes progression.

Disease insights from PPI

Kuzmanov and Emili review recent advances in protein-protein interaction studies from various model organisms, shedding light on the mechanisms and possible treatments for human disease.

Neuroprotective effects of D-Ala2GIP

A new long-lasting analogue of glucose-dependent insulinotropic polypeptide (GIP) has neuroprotective properties including rescuing cognitive performance and reducing Abeta plaque load and neuroinflammation in an animal model of Alzheimer's disease.

Matrix-directed differentiation of KPC

A specially designed matrix with potential applications in skin tissue engineering enables the selection of p63⁺ keratinocyte progenitor cells (KPC) from peripheral blood mononuclear cells, and favours their differentiation into epithelial cells.