Cancer Gateway

Welcome to BioMed Central's Cancer Gateway, highlighting the latest articles we have published in this field. Content is continually updated, so please bookmark this page and ensure you check it regularly.

Articles

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  • Fat cells interfering with breast cancer treatment

    Adipose cells in the tumour microenvironment may be contributing to resistance to Trastuzumab, a targeted treatment for HER2+ breast cancer.

    Breast Cancer Research 2015, 17:57
  • piRNA involvement in genome stability and human cancer

    Moyano and Stefani review key evidence for the role of piRNAs and PIWI in cancers deriving from both germline cells and somatic tissues, and how we can discriminate between a ‘passenger’ vs. a ‘driver’ role in the pathogenesis of these diseases.

    Journal of Hematology & Oncology 2015, 8:38
  • Long non-coding RNA predicts breast cancer prognosis

    Long non-coding RNA profiles were found to predict risk of metastases in lymph node-negative breast cancer patients, and hence may be a source of prognostic information used to combat overtreatment.

    Breast Cancer Research 2015, 17:55
  • CRISPR-Cas technologies for genome-scale investigation of disease processes

    Humphrey and Kasinski report on recently developed CRISPR-Cas platforms for global genome editing and address the therapeutic potential of CRISPR-Cas technology for genome-wide functional studies of disease processes, as well as applications beyond genome editing.

    Journal of Hematology & Oncology 2015, 8:31
  • ceRNAs: tying the essential knots for cancer biology and therapeutics

    Sanchez-Mejias and Tay review recent discoveries that implicate competing endogenous RNAs (ceRNAs), or natural miRNA sponges, in human cancer. The authors explain how identifying ceRNA regulatory networks can aid the development of new approaches to cancer diagnostics and oligonucleotide-based therapeutics.

    Journal of Hematology & Oncology 2015, 8:30
  • Image attributed to: By Maggie Bartlett, NHGRI - CC

    Urine testing for breast cancer

    The levels of four urinary miRNAs that are specifically altered in breast cancer patients compared to healthy controls may serve as potential non-invasive innovative biomarkers to detect primary breast cancer.

    BMC Cancer 2015, 15:193
  • Image attributed to: From Fig 1C Platt et al, BMC Cancer 15: 171 - CC

    The point on genomics-driven oncology

    Nicola Normanno and Ian Cree comment on the role of genomics in oncology, and the issues to overcome before targeted treatment based on genomic profile can become routinely accessible to lung cancer patients.

    BMC Cancer 2015, 15:141
  • Image attributed to: From Fig 4, Vikes? et al, BMC Cancer 15:151

    Molecular features of CUPs

    Cancers of unknown primary origin (CUP) exhibit distinct molecular features compared to metastases of known origin and display signatures of chromosome instability which may account for their uncommon clinical presentation and poor outcome.

    BMC Cancer 2015, 15:151

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