In this study, the stabilities of all core domain missense mutations are predicted and are used to infer their likely inactivation mechanisms. Our correlation analysis shows that loss of protein-protein contacts may be an alternative cause for p53 inactivation.

Invasive breast cancer rates have declined dramatically in the US, particularly in urban, affluent counties compared to their less well-off counterparts, potentially reflecting concurrent reductions in the use of hormone therapy.

Activation of growth factor (GF) signalling contributes to the tamoxifen-insensitive estrogen receptor-positive breast cancer phenotype independent of human epidermal growth factor receptor (HER2) gene expression, suggesting an alternative therapeutic target for this aggressive disease.

In order to improve early diagnosis and management of diseases such as ovarian cancer it is imperative that all pertinent information relating to referral, investigation and diagnosis is recorded in electronic patient records.

A small clinical trial has shown masitinib to be generally well tolerated and effective in the treatment of rheumatoid arthritis, indicating the need for further placebo-controlled studies.

Professor Ricardo Saban
Health Services Center, University of Oklahoma, USA