Cancer Gateway

Welcome to BioMed Central's Cancer Gateway, highlighting the latest articles we have published in this field. Content is continually updated, so please bookmark this page and ensure you check it regularly.


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  • How metformin acts against cancer

    Commenting on a recent paper in Cancer and Metabolism, Matthew vander Heiden and colleagues consider the mechanisms by which the anti-diabetic drug metformin can act via mitochondria to combat cancer.

    BMC Biology 2014, 12:82
  • Image attributed to: Image credit: Chandel, BMC Biology 2014

    Four requirements for metformin to arrest tumors

    Navdeep Chandel explains in an interview why it has been difficult to establish whether the anti-diabetic drug metformin affects tumor growth, and how the properties of individual tumors may be crucial.

    BMC Biology 2014, 12:85
  • Image attributed to: David, Wikimedia Commons

    Aging, metabolism and cancer

    David Gius and colleagues review the evidence that sirtiuns are tumor suppressor proteins that regulate mitochondrial metabolism, thereby linking aging mechanisms with carcinogenesis

    Cancer & Metabolism 2014, 2:15
  • Image attributed to: Image credit: Alice Plane, BMC Biology

    Cancer cell signaling: What goes wrong?

    As the latest addition to our series of Open Questions, Steven Wiley focuses on the feedback controls on cell signaling and proliferation, and the need to understand how they are disrupted in cancer cells.

    BMC Biology 2014, 12:88
  • Image attributed to: Wikipedia, CCMesserWoland

    Genes, environment & breast cancer

    Evidence suggests that gene-environment interactions could modify breast cancer risk; Olivia Fletcher and Frank Dudbridge discuss progress in elucidating these interactions, highlighting that further validation in large cohort studies is required.

    BMC Medicine 2014, 12:195


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Biomarker Research, a new journal encompassing all aspects biomarker investigation, has now launched. Visit the journal website to read the first articles, including a review by co-Editor-in-Chief Delong Liu on the clinical applications of JAK inhibitors, and sign up for article alerts.