From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms

Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.

Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma

Li Ding highlights recent findings suggesting that tumor cells with different driver mutations may coevolve rather than compete during clonal evolution

Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)

A novel anti-cancer drug diindolylmethane (DIM) prevents ovarian cancer cell growth by blocking STAT3, and enhances the tumor suppressive effects of the chemotherapy drug cisplatin, providing a potential new therapy for cisplatin-resistant tumors.

Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells

Luteolin, a flavonoid found in fruits and vegetables, reduces insulin-like growth factor-I receptor (IGF-IR) signaling in colon cancer cells, suggesting that this mechanism may contribute to luteolin-induced apoptosis and cell cycle arrest.

MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7

MicroRNA let-7a binds directly to the 3'UTR of C-C chemokine receptor type 7 (CCR7), blocking its protein expression and suppressing migration and invasion of breast cancer cells.