Cancer Gateway

While low-level laser therapy can reduce proliferation of melanoma cells in vitro, administration at high doses increases tumor growth in vivo, which suggests that this type of irradiation should be avoided over melanomas.

This paper details a live-cell method for measuring a nanosecond pulsed electric field distribution, providing an operationally meaningful calibration for electrode designs for biological applications and permitting visualization of the relative sensitivities of different cell types to nanoelectropulse stimulation.

Testing for human papillomavirus from the age of 25 followed by triage with Pap smears every three years is likely to prove more cost-effective for prevention of cervical cancer than some screening strategies currently in place.

Phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors originally designed to protect cells from cell-death under stress conditions efficiently eradicate breast cancer cells without impairing normal proliferating or non-proliferating cells.

Signal Transducer and Activator of Transcription 1 (STAT1) regulates energy metabolic pathways in tumors, predominantly via glycolytic genes, suggesting a role for STAT1 as a transcriptional modulator of genes involved in "Warburg effect" cancer cell energy production.

Professor Ricardo Saban
Health Services Center, University of Oklahoma, USA