Bioinformatics and Genomics Gateway

Modeling protein-protein interfaces involving an alpha helix

Computational analysis of proteins that interact with alpha-helical peptides suggests no sequence requirements for binding and highlights the presence of hydrophobic regions at the protein surface and non-uniform hydrophobicity across binding pockets.

Less painful CT colonography

Administration of an intravenous alfentanil bolus before CT colonography significantly reduces pain during colonic insufflation compared to administration of a placebo and could improve acceptance of CT colonography for colorectal cancer screening

Antipsychotic drug side effects investigated

Pomaglumetad methionil, a potential new glutamatergic based antipsychotic drug, has a low association with side effects such as weight gain and extrapyramidal symptoms, although evidence for treatment efficacy is low.

Assessment of a novel GPR40 agonist in the diabetic rat

Rats treated with CNX-011-67 demonstrate improved glucose mediated insulin secretion and insulin gene transcription, enhanced glucose oxidation in the form of increased islet ATP content and overall improvement in beta cell health.

Mechanism for fibrogenic effects of adenosine

Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.