Bioinformatics and Genomics Gateway

Statins reduce testosterone levels

According to a meta-analysis, treatment with statins, a drug commonly prescribed to patients at risk of cardiovascular disease, can reduce testosterone levels in both men and women, although the cause for this needs to be determined by further studies.

Effective combined diabetes therapy

In a 102 week trial, addition of dapagliflozin to metformin therapy for type 2 diabetes patients was effective for glycemic control in those who are inadequately controlled by metformin alone, suggesting a novel therapeutic option for those requiring long-term management.

Nematode model of early exposure to genotoxicants

Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.

Gout therapy: indomethacin more effective than rilonacept

Treatment with indomethacin alone in patients with acute gout flare is more effective than treatment with rilonacept and no greater pain relief is provided when used in combination with rilonacept. 

Pharmacogenomics of adverse drug reactions

Ann Daly reviews progress in identification of pharmacogenomic risk factors for serious adverse drug reactions, including different approaches used, and prospects for further progress.