Bioinformatics and Genomics Gateway

Welcome to the BioMed Central Bioinformatics and Genomics gateway, highlighting the latest news and information from BioMed Central and from across the web, on Bioinformatics and Genomics.

Articles

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  • Image attributed to: pixabay

    PDE5 inhibitors have cardioprotective effects

    Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat erectile dysfunction; evidence from a meta-analysis suggests that these drugs also protect against cardiac remodelling, indicating that they could be used to treat heart disease.

    BMC Medicine 2014, 12:185
  • Image attributed to: From Fig 2 from Zhao and colleagues

    Protein pockets guide cancer driver discovery

    A computational approach to investigate 1.2 million somatic mutations in 36 cancer types using 3D protein structure information to identify putative cancer drivers and drug response biomarkers.

    Genome Medicine 2014, 6:81
  • Image attributed to: istock

    Combined therapy may help heavy smokers

    A clinical trial finds a combination of varenicline and nicotine patches improves smoking cessation when compared to varenicline alone, but only in heavier smokers, warranting further work to confirm this finding.

    BMC Medicine 2014, 12:172
  • MUSIC

    A method for identifying enriched regions in ChIP-Seq experiments

    Genome Biology 2014, 15:474
  • FunSeq2

    FunSeq2 annotates and prioritizes noncoding driver mutations from somatic alterations by incorporating large-scale genomics and cancer resources

    Genome Biology 2014, 15:480

News and events

Human Genomics has now launched and is accepting submissions

Previously published by Henry Stewart Publications, Human Genomics has now launched and is accepting submissions under BioMed Central's open access platform. Edited by Prof. Vasilis Vasiliou, the journal aims to facilitate rapid publication and stimulate discussion within the human genomic field. The journal welcomes manuscripts relating to the application of genomic analysis in the understanding, treatment and diagnosis of complex and Mendelian diseases, as well as reports of the genomic analysis of adverse drug reactions, drug efficacy and safety.

Submit your manuscript online, and receive updates on this innovative journal's activities and publications by signing up for alerts.

Hot topics

Cancer biomarkers

Research

Decreased expression of prenyl diphosphate synthase subunit 2 correlates with reduced survival of patients with gastric cancer

Kanda M, Nomoto S, Oya H, Hashimoto R, Takami H, Shimizu D, Sonohara F, Kobayashi D et al.

Journal of Experimental & Clinical Cancer Research 2014, 33:88

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Metagenomics

Perspective

Reconceptualizing major depressive disorder as an infectious disease

Canli T

Biology of Mood & Anxiety Disorders 2014, 4:10

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Clinical proteomics

Review

Allergy-associated T cell epitope repertoires are surprisingly diverse and include non-IgE reactive antigens

Frazier A, Schulten V, Hinz D, Oseroff C, Sidney J, Peters B and Sette A

World Allergy Organization Journal 2014, 7:26

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