Welcome to the BioMed Central RNAi gateway, highlighting the latest BioMed Central articles, interesting news, and relevant external sites offering insight into the application of RNAi pathways in experimental biology.
An extensive screen of virus genomes for the stem-loop structure s2m found it in four virus families, Astroviridae, Caliciviridae, Picornaviridae and Coronaviridae, suggesting it is a mobile element with possible RNAi activity.
Oxidative stress may promote cardiac differentiation of adult stem or progenitor cells by increasing Notch1 signalling, potentially improving cell-based therapy for cardiac repair and regeneration.
For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
Reduced RNA-binding motif protein 3 (RBM3) expression is associated with more aggressive tumours and reduced survival rates in patients with urothelial bladder cancer, and could be used as a prognostic biomarker for treatment stratification in patients with this disease.
An analysis of the effect of copy number variation on growth, apoptosis and the cell cycle for a selected subset of Saccharomyces cerevisiae genes suggests that using this model yeast to predict the effects of similar copy number variants in human cancers is a worthwhile approach.
RNA: Methods and Protocols
A new thematic series, now accepting submissions
Silence is inviting submissions for a new article series on methods and protocols in analyzing RNA.
This special collection of articles will provide novel insights into the latest methods within the field of RNA, addressing questions of general interest to the RNA community, as well as predictions on future uses, modifications and improvements that would advance existing methods beyond their current use.
To submit your manuscript, please use our online submission system and indicate in your covering letter that you would like it to be considered for the series, or alternatively, send a pre-submission enquiry to firstname.lastname@example.org.
Gretchen Stone Cook Professor of Biomedical Sciences
Investigator, Howard Hughes Medical Institute
Co-Director, RNA Therapeutics Institute