RNAi Gateway

Welcome to the BioMed Central RNAi gateway, highlighting the latest BioMed Central articles, interesting news, and relevant external sites offering insight into the application of RNAi pathways in experimental biology.

Articles

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Identifying gaps in breast cancer research

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

Breast Cancer Research 2013, 15:R92
Neurexins

A Protein Family Review by Markus Missler and colleagues considers the role of neurexins in synaptic function and, consequently, neurological conditions

Genome Biology 2013, 14:213
TFs and methylation

Tet2 and DNMT3b act in concert with the transcription factor PU.1 to remodel the epigenome during monocyte-to-osteoclast differentiation

Genome Biology 2013, 14:R99
Targeting microspheres to mesothelioma

Silica microparticles loaded with doxorubicin (DOX) and modified with a mesothelin specific antibody demonstrate higher effectiveness and lower toxicity than DOX systemic treatment in a mouse xenograft model of human peritoneal mesothelioma.

BMC Cancer 2013, 13:400
New drugs that target cancer metabolism

Quinoline 3-sulfonamids were found to inhibit lactate dehydrogenease, a key driver of oncogenesis through altered cell metabolism, providing information about a potential new class of therapeutics.

Cancer & Metabolism 2013, 1:19

RNA: Methods and Protocols

A new thematic series, now accepting submissions

Silence is inviting submissions for a new article series on methods and protocols in analyzing RNA.

This special collection of articles will provide novel insights into the latest methods within the field of RNA, addressing questions of general interest to the RNA community, as well as predictions on future uses, modifications and improvements that would advance existing methods beyond their current use.

To submit your manuscript, please use our online submission system and indicate in your covering letter that you would like it to be considered for the series, or alternatively, send a pre-submission enquiry to editorial@silencejournal.com.