RNAi Gateway

Heregulin and EGF bind the same receptor and induce similar early responses in breast cancer cells, but a later sequence of transcription factors induced only by heregulin, including FosL1 and FHL2, suppresses ERK signaling to give differentiation rather than proliferation

The microRNAs miR-145, miR-126, miR-24 and miR-23a are selectively expressed in microvascular fragments in vivo, and miR-145 blocks migration in response to growth factor gradients, offering a novel therapeutic candidate for vascular disease.

An approach to identifying the physiological targets of ubiquitin receptors and the biological circuits they regulate is validated by screening for genes whose overexpression slows the growth of yeast cells lacking the ubiquitin-binding proteins Rad23 and Dsk2

Phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors originally designed to protect cells from cell-death under stress conditions efficiently eradicate breast cancer cells without impairing normal proliferating or non-proliferating cells.

A major genome-wide transposon mutagenesis screen in the red flour beetle sets the scene for future genetic analyses in this increasingly important model organism, and the same screening procedure can be potentially applied to other insects.