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	1. 32336 Accesses	Research article The smallest chemical reaction system with bistability Thomas Wilhelm BMC Systems Biology 2009, 3:90 (8 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The smallest bistable system contains just two reactants and four irreversible reactions, and it reveals that the necessary conditions for bistability are positive feedback, filtering out small stimuli, and a mechanism to prevent 'explosion' of the system.
	2. 17590 Accesses	Research article Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart Fan Wu, Daniel A Beard BMC Systems Biology 2009, 3:22 (19 February 2009) Abstract \| Full text \| PDF \| PubMed
	3. 16388 Accesses	Review A review of imaging techniques for systems biology Armen R Kherlopian, Ting Song, Qi Duan, Mathew A Neimark, Ming J Po, John K Gohagan, Andrew F Laine BMC Systems Biology 2008, 2:74 (12 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	4. 13145 Accesses	Research article Identification of functional modules using network topology and high-throughput data Igor Ulitsky, Ron Shamir BMC Systems Biology 2007, 1:8 (26 January 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Connected subnetworks of functionally related proteins are discovered by a novel computational technique integrating analysis of topological properties of gene and protein networks and information obtained from high-throughput experiments.
	5. 12984 Accesses	Research article Understanding network concepts in modules Jun Dong, Steve Horvath BMC Systems Biology 2007, 1:24 (4 June 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	6. 12034 Accesses	Research article Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis Laxman Yetukuri, Mikko Katajamaa, Gema Medina-Gomez, Tuulikki Seppänen-Laakso, Antonio Vidal-Puig, Matej Orešič BMC Systems Biology 2007, 1:12 (15 February 2007) Abstract \| Full text \| PDF \| PubMed
	7. 11472 Accesses	Software Structural and functional analysis of cellular networks with CellNetAnalyzer Steffen Klamt, Julio Saez-Rodriguez, Ernst D Gilles BMC Systems Biology 2007, 1:2 (8 January 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary CellNetAnalyzer provides a toolbox to examine functional states and dependencies of both metabolic and signaling networks, and to predict the effects of perturbations.
	8. 11132 Accesses	Research article Evaluating diabetes and hypertension disease causality using mouse phenotypes Hong Yu, Jialiang Huang, Nan Qiao, Christopher D Green, Jing-Dong J Han BMC Systems Biology 2010, 4:97 (20 July 2010) Abstract \| Full text \| PDF \| PubMed
	9. 10771 Accesses	Research article An integrated genetic, genomic and systems approach defines gene networks regulated by the interaction of light and carbon signaling pathways in Arabidopsis Karen E Thum, Michael J Shin, Rodrigo A Gutiérrez, Indrani Mukherjee, Manpreet S Katari, Damion Nero, Dennis Shasha, Gloria M Coruzzi BMC Systems Biology 2008, 2:31 (4 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	10. 10424 Accesses	Commentary Optimization in computational systems biology Julio R Banga BMC Systems Biology 2008, 2:47 (28 May 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	11. 10147 Accesses	Research article targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis Karthik Raman, Kalidas Yeturu, Nagasuma Chandra BMC Systems Biology 2008, 2:109 (19 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	12. 10079 Accesses	Research article A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory Juan Nogales, Bernhard Ø Palsson, Ines Thiele BMC Systems Biology 2008, 2:79 (16 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 10033 Accesses	Commentary Models for synthetic biology Yiannis N Kaznessis BMC Systems Biology 2007, 1:47 (6 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	14. 9782 Accesses	Methodology article Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery William J Bosl BMC Systems Biology 2007, 1:13 (15 February 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	15. 9686 Accesses	Research article Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo Jesse J Smith, Renée Kenney, David J Gagne, Brian P Frushour, William Ladd, Heidi L Galonek, Kristine Israelian, Jeffrey Song, Giedre Razvadauskaite, Amy V Lynch, David P Carney, Robin J Johnson, Siva Lavu, Andre Iffland, Peter J Elliott, Philip D Lambert, Keith O Elliston, Michael R Jirousek, Jill C Milne, Olivier Boss BMC Systems Biology 2009, 3:31 (10 March 2009) Abstract \| Full text \| PDF \| PubMed
	16. 9565 Accesses	Research article Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets Neema Jamshidi, Bernhard Ø Palsson BMC Systems Biology 2007, 1:26 (8 June 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	17. 9409 Accesses	Correspondence A framework for evolutionary systems biology Laurence Loewe BMC Systems Biology 2009, 3:27 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	18. 9358 Accesses	Methodology article From correlation to causation networks: a simple approximate learning algorithm and its application to high-dimensional plant gene expression data Rainer Opgen-Rhein, Korbinian Strimmer BMC Systems Biology 2007, 1:37 (6 August 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	19. 9065 Accesses	Research article Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii Nanette R Boyle, John A Morgan BMC Systems Biology 2009, 3:4 (7 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	20. 8714 Accesses	Research article Connecting extracellular metabolomic measurements to intracellular flux states in yeast Monica L Mo, Bernhard Ø Palsson, Markus J Herrgård BMC Systems Biology 2009, 3:37 (25 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	21. 8669 Accesses	Research article A Novel microRNA and transcription factor mediated regulatory network in schizophrenia An-Yuan Guo, Jingchun Sun, Peilin Jia, Zhongming Zhao BMC Systems Biology 2010, 4:10 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22. 8501 Accesses	Methodology article Eigengene networks for studying the relationships between co-expression modules Peter Langfelder, Steve Horvath BMC Systems Biology 2007, 1:54 (21 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 8496 Accesses	Research article Receptor downregulation and desensitization enhance the information processing ability of signalling receptors Harish Shankaran, H Steven Wiley, Haluk Resat BMC Systems Biology 2007, 1:48 (9 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Downregulation and desensitization of cell surface receptors creates a strong link between variation in ligands over time and cell signaling; in an engineering analogy, this is an overdamped oscillator, with receptor attenuation stabilizing the system.
	24. 8301 Accesses	Research article Reconstruction and analysis of the genetic and metabolic regulatory networks of the central metabolism of Bacillus subtilis Anne Goelzer, Fadia Bekkal Brikci, Isabelle Martin-Verstraete, Philippe Noirot, Philippe Bessières, Stéphane Aymerich, Vincent Fromion BMC Systems Biology 2008, 2:20 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new model of the Bacillus subtilis central metabolism identifies a set of locally regulated modules coordinated by global regulators and suggests that metabolite pools play an important role in regulation.
	25. 8147 Accesses	Research article Seeded Bayesian Networks: Constructing genetic networks from microarray data Amira Djebbari, John Quackenbush BMC Systems Biology 2008, 2:57 (4 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central