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	1. 1309 Accesses	Research article The genetic control of growth rate: a systems biology study in yeast. Pinar Pir, Alex Gutteridge, Jian Wu, Bharat Rash, Douglas B Kell, Nianshu Zhang, Stephen G Oliver BMC Systems Biology 2012, 6:4 (13 January 2012) Abstract \| Provisional PDF \| PubMed
	2. 957 Accesses	Software FAME, the Flux Analysis and Modeling Environment Joost Boele, Brett G Olivier, Bas Teusink BMC Systems Biology 2012, 6:8 (30 January 2012) Abstract \| Provisional PDF \| PubMed
	3. 785 Accesses	Research article Identifying co-targets to fight drug resistance based on a random walk model Liang-Chun Chen, Hsiang-Yuan Yeh, Cheng-Yu Yeh, Carlos Roberto Arias, Von-Wun Soo BMC Systems Biology 2012, 6:5 (19 January 2012) Abstract \| Provisional PDF \| PubMed
	4. 599 Accesses	Research article Biomarker robustness reveals the PDGF network as driving disease outcome in ovarian cancer patients in multiple studies Rotem Ben-Hamo, Sol Efroni BMC Systems Biology 2012, 6:3 (11 January 2012) Abstract \| Provisional PDF \| PubMed
	5. 567 Accesses	Research article Regulatory interactions for iron homoeostatis in Aspergillus fumigatus inferred by a Systems Biology approach Jorg Linde, Peter Hortschansky, Eugen Fazius, Axel A Brakhage, Reinhard Guthke, Hubertus Haas BMC Systems Biology 2012, 6:6 (19 January 2012) Abstract \| Provisional PDF \| PubMed
	6. 553 Accesses	Methodology article Rule-based multi-level modeling of cell biological systems Carsten Maus, Stefan Rybacki, Adelinde M Uhrmacher BMC Systems Biology 2011, 5:166 (17 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary ML-Rules is a formal modeling language for implementing rule-based modeling of biochemical systems at multiple levels with bidirectional causation between them, simplifying construction of hierarchical multi-level models for general users.
	7. 538 Accesses	Research article Evolvability of feed-forward loop architecture biases its abundance in transcription networks. Stefanie Widder, Ricard Sole, Javier Macia BMC Systems Biology 2012, 6:7 (19 January 2012) Abstract \| Provisional PDF \| PubMed
	8. 490 Accesses	Research article Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control Kevin M D'Auria, Gina M Donato, Mary C Gray, Glynis L Kolling, Cirle A Warren, Lauren M Cave, Michael D Solga, Joanne A Lannigan, Jason A Papin, Erik L Hewlett BMC Systems Biology 2012, 6:2 (6 January 2012) Abstract \| Full text \| PDF \| PubMed
	9. 475 Accesses	Research article Modelling of leishmaniasis infection dynamics: novel application to the design of effective therapies Bettina M Laenger, Cristina Pou-Barreto, Carlos Gonzalez-Alcon, Basilio Valladares, Bettina Wimmer, Nestor V. Torres BMC Systems Biology 2012, 6:1 (5 January 2012) Abstract \| Provisional PDF \| PubMed
	10. 466 Accesses	Research article Predicting outcomes of steady-state 13C isotope tracing experiments with Monte Carlo sampling Jan Schellenberger, Daniel C Zielinski, Wing Choi, Sunthosh Madireddi, Vasiliy Portnoy, David A Scott, Jennifer L Reed, Andrei L Osterman, Bernhard O Palsson BMC Systems Biology 2012, 6:9 (30 January 2012) Abstract \| Provisional PDF \| PubMed
	11. 384 Accesses	Research article A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology Aarash Bordbar, Adam M Feist, Renata Usaite-Black, Joseph Woodcock, Bernhard O Palsson, Iman Famili BMC Systems Biology 2011, 5:180 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	12. 382 Accesses	Research article Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network Jin Wang, Martin Haubrock, Kun-Ming Cao, Xu Hua, Chen-Yu Zhang, Edgar Wingender, Jie Li BMC Systems Biology 2011, 5:199 (16 December 2011) Abstract \| Full text \| PDF \| PubMed
	13. 380 Accesses	Review A review of imaging techniques for systems biology Armen R Kherlopian, Ting Song, Qi Duan, Mathew A Neimark, Ming J Po, John K Gohagan, Andrew F Laine BMC Systems Biology 2008, 2:74 (12 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	14. 375 Accesses	Research article targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis Karthik Raman, Kalidas Yeturu, Nagasuma Chandra BMC Systems Biology 2008, 2:109 (19 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	15. 356 Accesses	Research article Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms Pablo Carbonell, Davide Fichera, Shashi B Pandit, Jean-Loup Faulon BMC Systems Biology 2012, 6:10 (6 February 2012) Abstract \| Provisional PDF \| PubMed
	16. 324 Accesses	Research article A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections Stewart T Chang, Nicolas Tchitchek, Debashis Ghosh, Arndt Benecke, Michael G Katze BMC Systems Biology 2011, 5:202 (22 December 2011) Abstract \| Provisional PDF \| PubMed
	17. 320 Accesses	Research article The evolution of metabolic networks of E. coli David J Baumler, Roman G Peplinski, Jennifer L Reed, Jeremy D Glasner, Nicole T Perna BMC Systems Biology 2011, 5:182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed
	18. 310 Accesses	Research article Heterogeneity Reduces Sensitivity of Cell Death for TNF-Stimuli Monica Schliemann, Eric Bullinger, Steffen Borchers, Frank Allgower, Rolf Findeisen, Peter Scheurich BMC Systems Biology 2011, 5:204 (28 December 2011) Abstract \| Provisional PDF \| PubMed
	19. 293 Accesses	Research article Receptor downregulation and desensitization enhance the information processing ability of signalling receptors Harish Shankaran, H Steven Wiley, Haluk Resat BMC Systems Biology 2007, 1:48 (9 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Downregulation and desensitization of cell surface receptors creates a strong link between variation in ligands over time and cell signaling; in an engineering analogy, this is an overdamped oscillator, with receptor attenuation stabilizing the system.
	20. 290 Accesses	Research article Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii Nanette R Boyle, John A Morgan BMC Systems Biology 2009, 3:4 (7 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	21. 270 Accesses	Research article Inferring causal genomic alterations in breast cancer using gene expression data Linh M Tran, Bin Zhang, Zhan Zhang, Chunsheng Zhang, Tao Xie, John R Lamb, Hongyue Dai, Eric E Schadt, Jun Zhu BMC Systems Biology 2011, 5:121 (1 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Systematic identification of causal copy number variations (CNVs) in breast cancer gene expression data using a wavelet based method to distinguish "driver genes" from "passenger genes" identifies known oncogenes and novel susceptibility genes.
	22. 260 Accesses	Research article The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions Ottar Rolfsson, Bernhard Ø Palsson, Ines Thiele BMC Systems Biology 2011, 5:155 (1 October 2011) Abstract \| Full text \| PDF \| PubMed
	23. 257 Accesses	Research article DnaA and the timing of chromosome replication in Escherichia coli as a function of growth rate Matthew AA Grant, Chiara Saggioro, Ulisse Ferrari, Bruno Bassetti, Bianca Sclavi, Marco Cosentino Lagomarsino BMC Systems Biology 2011, 5:201 (21 December 2011) Abstract \| Provisional PDF \| PubMed
	24. 257 Accesses	Research article Initial characterization of the human central proteome Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge BMC Systems Biology 2011, 5:17 (26 January 2011) Abstract \| Full text \| PDF \| PubMed
	25. 257 Accesses	Research article Network analysis of microRNAs and their regulation in human ovarian cancer Sebastian Schmeier, Ulf Schaefer, Magbubah Essack, Vladimir B Bajic BMC Systems Biology 2011, 5:183 (3 November 2011) Abstract \| Full text \| PDF \| PubMed