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Research article   Open Access

Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network

Robert Modre-Osprian, Ingrid Osprian, Bernhard Tilg, Günter Schreier, Klaus M Weinberger, Armin Graber BMC Systems Biology 2009, 3:2 (6 January 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

Özgür Sahin, Holger Fröhlich, Christian Löbke, Ulrike Korf, Sara Burmester, Meher Majety, Jens Mattern, Ingo Schupp, Claudine Chaouiya, Denis Thieffry, Annemarie Poustka, Stefan Wiemann, Tim Beissbarth, Dorit Arlt BMC Systems Biology 2009, 3:1 (1 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Metabolic pathway alignment between species using a comprehensive and flexible similarity measure

Yunlei Li, Dick de Ridder, Marco JL de Groot, Marcel JT Reinders BMC Systems Biology 2008, 2:111 (24 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Both conserved and unique pathways can be identified by employing a new framework, Metabolic Pathway Alignment and Scoring (M-PAS), based on comparative analysis of metabolic networks between species.

Research article   Open Access

Essential operating principles for tumor spheroid growth

Jesse A Engelberg, Glen EP Ropella, C Anthony Hunt BMC Systems Biology 2008, 2:110 (23 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis

Karthik Raman, Kalidas Yeturu, Nagasuma Chandra BMC Systems Biology 2008, 2:109 (19 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Signal duration and the time scale dependence of signal integration in biochemical pathways

Jason W Locasale BMC Systems Biology 2008, 2:108 (17 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Modelling phagosomal lipid networks that regulate actin assembly

Mark Kühnel, Luis S Mayorga, Thomas Dandekar, Juilee Thakar, Roland Schwarz, Elsa Anes, Gareth Griffiths, Jens Reich BMC Systems Biology 2008, 2:107 (5 December 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates

André Fujita, Luciana Gomes, João Sato, Rui Yamaguchi, Carlos Thomaz, Mari Sogayar, Satoru Miyano BMC Systems Biology 2008, 2:106 (5 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

RNA silencing can explain chlorotic infection patterns on plant leaves

Marian AC Groenenboom, Paulien Hogeweg BMC Systems Biology 2008, 2:105 (30 November 2008)

Abstract | Full text | PDF | PubMed

Software   Open Access Highly Accessed

Arena3D: visualization of biological networks in 3D

Georgios A Pavlopoulos, Seán I O'Donoghue, Venkata P Satagopam, Theodoros G Soldatos, Evangelos Pafilis, Reinhard Schneider BMC Systems Biology 2008, 2:104 (28 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

A systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises

Bor-Sen Chen, Yu-Te Chang BMC Systems Biology 2008, 2:103 (27 November 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

From pathway to population – a multiscale model of juxtacrine EGFR-MAPK signalling

DC Walker, NT Georgopoulos, J Southgate BMC Systems Biology 2008, 2:102 (26 November 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks

Christopher R Bauer, Andrew M Epstein, Sarah J Sweeney, Daniela C Zarnescu, Giovanni Bosco BMC Systems Biology 2008, 2:101 (25 November 2008)

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Research article   Open Access Highly Accessed

The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles

Pawel Durek, Dirk Walther BMC Systems Biology 2008, 2:100 (25 November 2008)

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Research article   Open Access Highly Accessed

Dynamical modeling of the cholesterol regulatory pathway with Boolean networks

Gwenael Kervizic, Laurent Corcos BMC Systems Biology 2008, 2:99 (24 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model

Mariana Benítez, Carlos Espinosa-Soto, Pablo Padilla-Longoria, Elena R Alvarez-Buylla BMC Systems Biology 2008, 2:98 (17 November 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Stochastic analysis of the GAL genetic switch in Saccharomyces cerevisiae: Modeling and experiments reveal hierarchy in glucose repression

Vinay Prasad, KV Venkatesh BMC Systems Biology 2008, 2:97 (17 November 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Stochasticity or 'noise' in the transcriptional regulation of the GAL network in yeast depends on the number of binding sites involved and the mechanism of regulation, and has measurable effects on the growth of cells.

Research article   Open Access

Natural selection governs local, but not global, evolutionary gene coexpression networks in Caenorhabditis elegans

I King Jordan, Lee S Katz, Dee R Denver, J Todd Streelman BMC Systems Biology 2008, 2:96 (13 November 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access Highly Accessed

Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome

Angela P Presson, Eric M Sobel, Jeanette C Papp, Charlyn J Suarez, Toni Whistler, Mangalathu S Rajeevan, Suzanne D Vernon, Steve Horvath BMC Systems Biology 2008, 2:95 (6 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Genetic noise control via protein oligomerization

Cheol-Min Ghim, Eivind Almaas BMC Systems Biology 2008, 2:94 (3 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

An in silico method for detecting overlapping functional modules from composite biological networks

Ioannis A Maraziotis, Konstantina Dimitrakopoulou, Anastasios Bezerianos BMC Systems Biology 2008, 2:93 (1 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Dynamics of receptor and protein transducer homodimerisation

Julio Vera, Thomas Millat, Walter Kolch, Olaf Wolkenhauer BMC Systems Biology 2008, 2:92 (31 October 2008)

Abstract | Full text | PDF | PubMed

Software   Open Access

ALC: automated reduction of rule-based models

Markus Koschorreck, Ernst Gilles BMC Systems Biology 2008, 2:91 (31 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

From protein interactions to functional annotation: graph alignment in Herpes

Michal Kolář, Michael Lässig, Johannes Berg BMC Systems Biology 2008, 2:90 (28 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli

Jiangjun Cui, Jaap A Kaandorp, Catherine M Lloyd BMC Systems Biology 2008, 2:89 (24 October 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Using a 3D virtual muscle model to link gene expression changes during myogenesis to protein spatial location in muscle

Ashley J Waardenberg, Antonio Reverter, Christine A Wells, Brian P Dalrymple BMC Systems Biology 2008, 2:88 (22 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

A quantitative estimation of the global translational activity in logarithmically growing yeast cells

Tobias von der Haar BMC Systems Biology 2008, 2:87 (16 October 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Robust simplifications of multiscale biochemical networks

Ovidiu Radulescu, Alexander N Gorban, Andrei Zinovyev, Alain Lilienbaum BMC Systems Biology 2008, 2:86 (14 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Iterative reconstruction of a global metabolic model of Acinetobacter baylyi ADP1 using high-throughput growth phenotype and gene essentiality data

Maxime Durot, François Le Fèvre, Véronique de Berardinis, Annett Kreimeyer, David Vallenet, Cyril Combe, Serge Smidtas, Marcel Salanoubat, Jean Weissenbach, Vincent Schachter BMC Systems Biology 2008, 2:85 (7 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access

Network evaluation from the consistency of the graph structure with the measured data

Shigeru Saito, Sachiyo Aburatani, Katsuhisa Horimoto BMC Systems Biology 2008, 2:84 (1 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Parameter estimation and determinability analysis applied to Drosophila gap gene circuits

Maksat Ashyraliyev, Johannes Jaeger, Joke G Blom BMC Systems Biology 2008, 2:83 (25 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A study of gap gene circuits in Drosophila shows that gene network models can be strengthened by analyzing the quality of parameter estimates in order to distinguish reliable interactions from those which are ambiguous.

Research article   Open Access

Origin of structural difference in metabolic networks with respect to temperature

Kazuhiro Takemoto, Tatsuya Akutsu BMC Systems Biology 2008, 2:82 (22 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Employing conservation of co-expression to improve functional inference

Carsten O Daub, Erik LL Sonnhammer BMC Systems Biology 2008, 2:81 (22 September 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The accuracy of predictions of protein interactions may be improved by employing a cross-species strategy, comparing patterns of co-expressed genes from a number of species using popular co-expression distance measures.

Research article   Open Access Highly Accessed

The use of Gene Ontology terms for predicting highly-connected 'hub' nodes in protein-protein interaction networks

Michael Hsing, Kendall Byler, Artem Cherkasov BMC Systems Biology 2008, 2:80 (16 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory

Juan Nogales, Bernhard Ø Palsson, Ines Thiele BMC Systems Biology 2008, 2:79 (16 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access

Exact model reduction of combinatorial reaction networks

Holger Conzelmann, Dirk Fey, Ernst D Gilles BMC Systems Biology 2008, 2:78 (28 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

A compartment model of VEGF distribution in blood, healthy and diseased tissues

Marianne O Stefanini, Florence TH Wu, Feilim Mac Gabhann, Aleksander S Popel BMC Systems Biology 2008, 2:77 (19 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

Rapidly exploring structural and dynamic properties of signaling networks using PathwayOracle

Derek Ruths, Luay Nakhleh, Prahlad T Ram BMC Systems Biology 2008, 2:76 (19 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Explaining oscillations and variability in the p53-Mdm2 system

Carole J Proctor, Douglas A Gray BMC Systems Biology 2008, 2:75 (18 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

A review of imaging techniques for systems biology

Armen R Kherlopian, Ting Song, Qi Duan, Mathew A Neimark, Ming J Po, John K Gohagan, Andrew F Laine BMC Systems Biology 2008, 2:74 (12 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Research article   Open Access Highly Accessed

On the origin of distribution patterns of motifs in biological networks

Arun S Konagurthu, Arthur M Lesk BMC Systems Biology 2008, 2:73 (12 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

Wei Jiang, Xia Li, Shaoqi Rao, Lihong Wang, Lei Du, Chuanxing Li, Chao Wu, Hongzhi Wang, Yadong Wang, Baofeng Yang BMC Systems Biology 2008, 2:72 (10 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism

Intawat Nookaew, Michael C Jewett, Asawin Meechai, Chinae Thammarongtham, Kobkul Laoteng, Supapon Cheevadhanarak, Jens Nielsen, Sakarindr Bhumiratana BMC Systems Biology 2008, 2:71 (7 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

An enzyme-centric approach for modelling non-linear biological complexity

Chin-Rang Yang BMC Systems Biology 2008, 2:70 (1 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Structural similarity of genetically interacting proteins

Oranit Dror, Dina Schneidman-Duhovny, Alexandra Shulman-Peleg, Ruth Nussinov, Haim J Wolfson, Roded Sharan BMC Systems Biology 2008, 2:69 (31 July 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Modeling cellular deformations using the level set formalism

Liu Yang, Janet C Effler, Brett L Kutscher, Sarah E Sullivan, Douglas N Robinson, Pablo A Iglesias BMC Systems Biology 2008, 2:68 (24 July 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Machine learning based analyses on metabolic networks supports high-throughput knockout screens

Kitiporn Plaimas, Jan-Phillip Mallm, Marcus Oswald, Fabian Svara, Victor Sourjik, Roland Eils, Rainer König BMC Systems Biology 2008, 2:67 (24 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

GridCell: a stochastic particle-based biological system simulator

Laurier Boulianne, Sevin Al Assaad, Michel Dumontier, Warren J Gross BMC Systems Biology 2008, 2:66 (23 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Incorporation of enzyme concentrations into FBA and identification of optimal metabolic pathways

Rajat K De, Mouli Das, Subhasis Mukhopadhyay BMC Systems Biology 2008, 2:65 (18 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data

Zuyi Huang, Fatih Senocak, Arul Jayaraman, Juergen Hahn BMC Systems Biology 2008, 2:64 (17 July 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Multiway modeling and analysis in stem cell systems biology

Bülent Yener, Evrim Acar, Pheadra Aguis, Kristin Bennett, Scott L Vandenberg, George E Plopper BMC Systems Biology 2008, 2:63 (14 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

A systems approach to model natural variation in reactive properties of bacterial ribosomes

Julius H Jackson, Thomas M Schmidt, Patricia A Herring BMC Systems Biology 2008, 2:62 (13 July 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Exhaustive identification of steady state cycles in large stoichiometric networks

Jeremiah Wright, Andreas Wagner BMC Systems Biology 2008, 2:61 (11 July 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A

Paula Jouhten, Eija Rintala, Anne Huuskonen, Anu Tamminen, Mervi Toivari, Marilyn Wiebe, Laura Ruohonen, Merja Penttilä, Hannu Maaheimo BMC Systems Biology 2008, 2:60 (9 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Metabolic modelling of polyhydroxyalkanoate copolymers production by mixed microbial cultures

João ML Dias, Adrian Oehmen, Luísa S Serafim, Paulo C Lemos, Maria AM Reis, Rui Oliveira BMC Systems Biology 2008, 2:59 (8 July 2008)

Abstract | Full text | PDF | PubMed

Commentary   Open Access Highly Accessed

Short time-series microarray analysis: Methods and challenges

Xuewei Wang, Ming Wu, Zheng Li, Christina Chan BMC Systems Biology 2008, 2:58 (7 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Seeded Bayesian Networks: Constructing genetic networks from microarray data

Amira Djebbari, John Quackenbush BMC Systems Biology 2008, 2:57 (4 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets

Liang-Hui Chu, Bor-Sen Chen BMC Systems Biology 2008, 2:56 (30 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

The Systems Biology Research Tool: evolvable open-source software

Jeremiah Wright, Andreas Wagner BMC Systems Biology 2008, 2:55 (29 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The effects of protein interactions, gene essentiality and regulatory regions on expression variation

Linqi Zhou, Xiaotu Ma, Fengzhu Sun BMC Systems Biology 2008, 2:54 (26 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Systematic reconstruction of TRANSPATH data into Cell System Markup Language

Masao Nagasaki, Ayumu Saito, Chen Li, Euna Jeong, Satoru Miyano BMC Systems Biology 2008, 2:53 (23 June 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

A computational analysis of protein-protein interaction networks in neurodegenerative diseases

Joaquín Goñi, Francisco J Esteban, Nieves de Mendizábal, Jorge Sepulcre, Sergio Ardanza-Trevijano, Ion Agirrezabal, Pablo Villoslada BMC Systems Biology 2008, 2:52 (20 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Time-resolved metabolomics reveals metabolic modulation in rice foliage

Shigeru Sato, Masanori Arita, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita BMC Systems Biology 2008, 2:51 (18 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Can single knockouts accurately single out gene functions?

David Deutscher, Isaac Meilijson, Stefan Schuster, Eytan Ruppin BMC Systems Biology 2008, 2:50 (18 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Complex biological systems are often studied by single gene knockouts, however an in silico yeast model finds that single-perturbation analyzes frequently fail to reveal all the genes involved in a system or their full functions.

Research article   Open Access Highly Accessed

Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion

XiaoDong Huang, Jean YJ Wang, Xin Lu BMC Systems Biology 2008, 2:49 (13 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach

Najl V Valeyev, Declan G Bates, Pat Heslop-Harrison, Ian Postlethwaite, Nikolay V Kotov BMC Systems Biology 2008, 2:48 (2 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Commentary   Open Access Highly Accessed

Optimization in computational systems biology

Julio R Banga BMC Systems Biology 2008, 2:47 (28 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network

Susanne Reymann, Jürgen Borlak BMC Systems Biology 2008, 2:46 (22 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Defining a Modular Signalling Network from the Fly Interactome

Anaïs Baudot, Jean-Baptiste Angelelli, Alain Guénoche, Bernard Jacq, Christine Brun BMC Systems Biology 2008, 2:45 (19 May 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory

William J Heuett, Daniel A Beard, Hong Qian BMC Systems Biology 2008, 2:44 (15 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Mathematical modeling and analysis of insulin clearance in vivo

Markus Koschorreck, Ernst Gilles BMC Systems Biology 2008, 2:43 (13 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A detailed dynamic model of insulin clearance that incorporates insulin secretion, binding and degradation as well as receptor activity shows that the process of insulin clearance is non-linear and highly dependent upon blood insulin concentration.

Methodology article   Open Access

A Dominated Coupling From The Past algorithm for the stochastic simulation of networks of biochemical reactions

Martin Hemberg, Mauricio Barahona BMC Systems Biology 2008, 2:42 (8 May 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Extraction of elementary rate constants from global network analysis of E. coli central metabolism

Jiao Zhao, Douglas Ridgway, Gordon Broderick, Andriy Kovalenko, Michael Ellison BMC Systems Biology 2008, 2:41 (7 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access

Exploiting the pathway structure of metabolism to reveal high-order epistasis

Marcin Imielinski, Calin Belta BMC Systems Biology 2008, 2:40 (30 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

SBMLsqueezer: A CellDesigner plug-in to generate kinetic rate equations for biochemical networks

Andreas Dräger, Nadine Hassis, Jochen Supper, Adrian Schröder, Andreas Zell BMC Systems Biology 2008, 2:39 (30 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

SBMLsqueezer is a plug-in that automatically assigns kinetic equations to reactions in models for the popular CellDesigner biochemical network design software, implementing several classes of interactions and types of reaction kinetics.

Research article   Open Access Highly Accessed

A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway

Julio Vera, Julie Bachmann, Andrea C Pfeifer, Verena Becker, Jose A Hormiga, Nestor Darias, Jens Timmer, Ursula Klingmüller, Olaf Wolkenhauer BMC Systems Biology 2008, 2:38 (25 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Phenotype prediction in regulated metabolic networks

Christoph Kaleta, Florian Centler, Pietro di Fenizio, Peter Dittrich BMC Systems Biology 2008, 2:37 (25 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza, Kevin A Robertson, Paul A Lacaze, David Page, Anton J Enright, Peter Ghazal, Tom C Freeman BMC Systems Biology 2008, 2:36 (23 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Parameter optimization in S-system models

Marco Vilela, I-Chun Chou, Susana Vinga, Ana Vasconcelos, Eberhard O Voit, Jonas S Almeida BMC Systems Biology 2008, 2:35 (16 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Using genetic markers to orient the edges in quantitative trait networks: The NEO software

Jason E Aten, Tova F Fuller, Aldons J Lusis, Steve Horvath BMC Systems Biology 2008, 2:34 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Extracting expression modules from perturbational gene expression compendia

Steven Maere, Patrick Van Dijck, Martin Kuiper BMC Systems Biology 2008, 2:33 (10 April 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

An ultrasensitive sorting mechanism for EGF Receptor Endocytosis

Hannah Schmidt-Glenewinkel, Ivayla Vacheva, Daniela Hoeller, Ivan Dikic, Roland Eils BMC Systems Biology 2008, 2:32 (7 April 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

An integrated genetic, genomic and systems approach defines gene networks regulated by the interaction of light and carbon signaling pathways in Arabidopsis

Karen E Thum, Michael J Shin, Rodrigo A Gutiérrez, Indrani Mukherjee, Manpreet S Katari, Damion Nero, Dennis Shasha, Gloria M Coruzzi BMC Systems Biology 2008, 2:31 (4 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Optimal enumeration of state space of finitely buffered stochastic molecular networks and exact computation of steady state landscape probability

Youfang Cao, Jie Liang BMC Systems Biology 2008, 2:30 (29 March 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification

Tae Hoon Yang, Oliver Frick, Elmar Heinzle BMC Systems Biology 2008, 2:29 (26 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

The dynamics and efficacy of antiviral RNA silencing: A model study

Marian AC Groenenboom, Paulien Hogeweg BMC Systems Biology 2008, 2:28 (26 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency

Patrick Amar, Guillaume Legent, Michel Thellier, Camille Ripoll, Gilles Bernot, Thomas Nystrom, Milton H Saier, Vic Norris BMC Systems Biology 2008, 2:27 (25 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Hybrid optimization method with general switching strategy for parameter estimation

Eva Balsa-Canto, Martin Peifer, Julio R Banga, Jens Timmer, Christian Fleck BMC Systems Biology 2008, 2:26 (24 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

One hub-one process: a tool based view on regulatory network topology

Jacob Axelsen, Sebastian Bernhardsson, Kim Sneppen BMC Systems Biology 2008, 2:25 (4 March 2008)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access Highly Accessed

OptCircuit: An optimization based method for computational design of genetic circuits

Madhukar S Dasika, Costas D Maranas BMC Systems Biology 2008, 2:24 (3 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

Interactive analysis of systems biology molecular expression data

Mingwu Zhang, Qi Ouyang, Alan Stephenson, Michael D Kane, David E Salt, Sunil Prabhakar, John Burgner, Charles Buck, Xiang Zhang BMC Systems Biology 2008, 2:23 (29 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Global parameter search reveals design principles of the mammalian circadian clock

James CW Locke, Pål O Westermark, Achim Kramer, Hanspeter Herzel BMC Systems Biology 2008, 2:22 (29 February 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The regulatory network of E. coli metabolism as a Boolean dynamical system exhibits both homeostasis and flexibility of response

Areejit Samal, Sanjay Jain BMC Systems Biology 2008, 2:21 (29 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Large scale dynamical analysis of E. coli metabolism using Boolean rules demonstrates that the architecture of the genetic network is hierarchical, modular and largely acyclic, which makes these bacteria robust yet flexible in their response to environmental change.

Research article   Open Access Highly Accessed

Reconstruction and analysis of the genetic and metabolic regulatory networks of the central metabolism of Bacillus subtilis

Anne Goelzer, Fadia Bekkal Brikci, Isabelle Martin-Verstraete, Philippe Noirot, Philippe Bessières, Stéphane Aymerich, Vincent Fromion BMC Systems Biology 2008, 2:20 (26 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new model of the Bacillus subtilis central metabolism identifies a set of locally regulated modules coordinated by global regulators and suggests that metabolite pools play an important role in regulation.

Research article   Open Access

Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility

Divyaswetha Peddinti, Bindu Nanduri, Abdullah Kaya, Jean M Feugang, Shane C Burgess, Erdogan Memili BMC Systems Biology 2008, 2:19 (22 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Dissecting the logical types of network control in gene expression profiles

Carsten Marr, Marcel Geertz, Marc-Thorsten Hütt, Georgi Muskhelishvili BMC Systems Biology 2008, 2:18 (19 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks

Ana Oliveira, Kiran Patil, Jens Nielsen BMC Systems Biology 2008, 2:17 (8 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Connecting genes, coexpression modules, and molecular signatures to environmental stress phenotypes in plants

David J Weston, Lee E Gunter, Alistair Rogers, Stan D Wullschleger BMC Systems Biology 2008, 2:16 (4 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access

Equilibrium model selection: dTTP induced R1 dimerization

Tomas Radivoyevitch BMC Systems Biology 2008, 2:15 (4 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Three factors underlying incorrect in silico predictions of essential metabolic genes

Scott A Becker, Bernhard O Palsson BMC Systems Biology 2008, 2:14 (4 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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