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Volume 6 (2012) - March 2012

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Research article   Open Access

An optimally evolved connective ratio of neural networks that maximizes the occurrence of synchronized bursting behavior

Chao-Yi Dong, Kwang-Hyun Cho BMC Systems Biology 2012, 6:23 (31 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Redox balance is key to explaining full vs. partial switching to low-yield metabolism

Milan JA van Hoek, Roeland MH Merks BMC Systems Biology 2012, 6:22 (24 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Set membership experimental design for biological systems

Skylar W Marvel, Cranos M Williams BMC Systems Biology 2012, 6:21 (21 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Predicting new molecular targets for rhein using network pharmacology

Aihua Zhang, Hui Sun, Bo Yang, Xijun Wang BMC Systems Biology 2012, 6:20 (21 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis

Tian Xia, Jiansong Tong, Shailendra S Rathore, Xun Gu, Julie A Dickerson BMC Systems Biology 2012, 6:19 (16 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Crosstalk between transcription factors and microRNAs in human protein interaction network

Chen-Ching Lin, Ya-Jen Chen, Cho-Yi Chen, Yen-Jen Oyang, Hsueh-Fen Juan, Hsuan-Cheng Huang BMC Systems Biology 2012, 6:18 (13 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Structural analysis of eyespots: dynamics of morphogenic signals that govern elemental positions in butterfly wings

Joji M Otaki BMC Systems Biology 2012, 6:17 (13 March 2012)

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Methodology article   Open Access

Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations

Sabrina Kleessen, Zoran Nikoloski BMC Systems Biology 2012, 6:16 (12 March 2012)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access Highly Accessed

A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data

Min Li, Hanhui Zhang, Jian-xin Wang, Yi Pan BMC Systems Biology 2012, 6:15 (10 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

Irina Surovtsova, Natalia Simus, Katrin Hübner, Sven Sahle, Ursula Kummer BMC Systems Biology 2012, 6:14 (5 March 2012)

Abstract | Full text | PDF | PubMed


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