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Volume 1 (2007) - June 2007

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Commentary   Open Access Highly Accessed

The long journey to a Systems Biology of neuronal function

Nicolas Le Novère BMC Systems Biology 2007, 1:28 (13 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Neurobiology has led the way in computational modeling for over half a century, and now neurobiologists have no excuse not to be at the forefront of computational systems biology.

Research article   Open Access Highly Accessed

Non-linear dimensionality reduction of signaling networks

Sergii Ivakhno, J Douglas Armstrong BMC Systems Biology 2007, 1:27 (8 June 2007)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The effect of cytokines and growth factors on cellular signaling networks can be mapped using an extension of Isomap, an unsupervised approach that considers non-linear interactions, finding biologically meaningful responses when other approaches fail.

Research article   Open Access Highly Accessed

Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets

Neema Jamshidi, Bernhard Ø Palsson BMC Systems Biology 2007, 1:26 (8 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound

Helene M Langevin, Donna M Rizzo, James R Fox, Gary J Badger, Junru Wu, Elisa E Konofagou, Debbie Stevens-Tuttle, Nicole A Bouffard, Martin H Krag BMC Systems Biology 2007, 1:25 (5 June 2007)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Understanding network concepts in modules

Jun Dong, Steve Horvath BMC Systems Biology 2007, 1:24 (4 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Methodology article   Open Access

Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

Andreas Hoppe, Sabrina Hoffmann, Hermann-Georg Holzhütter BMC Systems Biology 2007, 1:23 (1 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central


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