- Nitin Baliga, Institute for Systems Biology
- Christina Chan, Michigan State University
- Luonan Chen, Chinese Academy of Sciences
- Sang Yup Lee, Korea Advanced Institute of Science and Technology
- Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
- Matteo Pellegrini, University of California, Los Angeles
- Tim Sands, BioMed Central
The size and complexity of genome-scale metabolic models means that analysis may be computationally impractical and stoichiometric methods unusable, but a new algorithm, NetworkReducer, extracts a meaningful core network to facilitate analysis.
Genome-wide regulatory networks underling urothelial cancer, inferred by the BC3Net algorithm based on RNAseq, Bead and Oligo gene expression data, identified known associated genomic regions, and found similarity between functional subnetworks but gene interactions were highly dataset specific.
A new flux balance analysis method predicts internal cell fluxes of growth below optimal rates based on the optimization of protein cost at sub-optimal biomass objective levels, and simulations predict features of E.coli central carbon metabolism.
Across ammonite genera, trade-offs between different shape phenotypes resulted in a small range of successful forms, that could be represented by a pyramid in the diagram of possible shape parameters, with each point representing an optimized archetype.
BMC Systems Biology 2015, 9:53
News from around the web
- 07 August 2015
- Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer
BMC Systems Biology is an open access, peer-reviewed journal that considers articles on experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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- 02 September 2015
- Behind the image: 3D home range of the California condor
- 01 September 2015
- The oldest and the scariest sea scorpion: a giant discovery
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- Improving rice for the future: an author Q+A
Volume 9 Suppl 5 (1 September 2015)
Selected articles from the IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2014): Systems Biology
Belfast, UK. 2-5 November 2014
Volume 9 Suppl 4 (11 June 2015)
Selected articles from the International Conference on Intelligent Biology and Medicine (ICIBM) 2014: Systems Biology
San Antonio, TX, USA. 4-6 December 2014
Volume 9 Suppl 3 (1 June 2015)
Rome, Italy. 26-28 February 2014