- Nitin Baliga, Institute for Systems Biology
- Christina Chan, Michigan State University
- Luonan Chen, Chinese Academy of Sciences
- Sang Yup Lee, Korea Advanced Institute of Science and Technology
- Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
- Matteo Pellegrini, University of California, Los Angeles
- Tim Sands, BioMed Central
The use of inhibitors to components of cancer signaling pathways is dogged by resistance and cross-talk upregulating compensatory pathways. A new computational framework characterizes the cross-talks between pathways in breast cancer cell lines.
A highly curated metabolic network model of the bacterium Clostridium difficile, which can cause serious hospital infections, predicts a number of essential genes presenting potential drug targets, some of which have homologs with existing inhibitory drugs.
An updated model of metabolism and protein expression in E. coli incorporates the role of four sub-cellular compartments, along with a reconstruction of protein translocation pathways, demonstrates the value of including compartmentalization in models to generate new biological insights
BMC Systems Biology 2015, 9:10
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BMC Systems Biology is an open access, peer-reviewed journal that considers articles on experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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Volume 9 Suppl 1 (21 January 2015)
Selected articles from the Thirteenth Asia Pacific Bioinformatics Conference (APBC 2015): Systems Biology
HsinChu, Taiwan. 21-23 January 2015
Volume 8 Suppl 5 (12 December 2014)
Proceedings of the 25th International Conference on Genome Informatics (GIW/ISCB-Asia): Systems Biology
Tokyo, Japan. 15-17 December 2014
Volume 8 Suppl 4 (8 December 2014)
Sydney, Australia. 31 July - 2 August 2014