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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Tim Sands, PhD
Welcome to BMC Systems Biology published by BioMed Central
BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology (ISSN 1752-0509) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Reuters (ISI) and Google Scholar.
BMC Systems Biology 2009, 3 :48
In Arabidopsis, an information value can be assigned for ethylene signals transmitted to activate ERF1 (Ethylene Response Factor 1) expression, demonstrating that information theory can be used to model any signaling pathway response to environmental input.
BMC Systems Biology 2009, 3 :23
Repeated duplication of phosphodiesterase (PDE) genes in sticklebacks has not led to new gene functions, but has resulted in increased gene dosage and expression in new organs such as the nose, where effects on olfactory transduction are predicted.
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Methodology article
BowTieBuilder: modeling signal transduction pathways Jochen Supper, Lucia Spangenberg, Hannes Planatscher, Andreas Draeger, Adrian Schroeder, Andreas Zell BMC Systems Biology 2009, 3 :67 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A systematic design method for robust synthetic biology to satisfy design specifications Bor-Sen Chen, Chih-Hung Wu BMC Systems Biology 2009, 3 :66 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Clustered microRNAs' coordination in regulating protein-protein interaction network Xiongying Yuan, Changning Liu, Pengcheng Yang, Shunmin He, Qi Liao, Shuli Kang, Yi Zhao BMC Systems Biology 2009, 3 :65 (26 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Stochastic simulation and analysis of biomolecular reaction networks
John M Frazier, Yaroslav Chushak, Brent Foy BMC Systems Biology 2009, 3 :64 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
The Symbiosis Interactome: a computational approach reveals novel components, functional interactions and modules in Sinorhizobium meliloti Ignacio Rodriguez-Llorente, Miguel A Caviedes, Mohammed Dary, Antonio J Palomares, Francisco M C BMC Systems Biology 2009, 3 :63 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Serial evolutionary networks of within-patient HIV-1 sequences reveal patterns of evolution of X4 strains Patricia Buendia, Giri Narasimhan BMC Systems Biology 2009, 3 :62 (16 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Intervention in gene regulatory networks via greedy control policies based on long-run behavior Xiaoning Qian, Ivan Ivanov, Noushin Ghaffari, Edward R Dougherty BMC Systems Biology 2009, 3 :61 (15 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
The mathematics of tanning Josef Thingnes, Leiv Oyehaug, Eivind Hovig, Stig W Omholt BMC Systems Biology 2009, 3 :60 (9 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A system biology approach highlights a hormonal enhancer effect on regulation of genes in a nitrate responsive "biomodule" Damion Nero, Gabriel Krouk, Daniel Tranchina, Gloria M Coruzzi BMC Systems Biology 2009, 3 :59 (6 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Software
ChemChains: a platform for simulation and analysis of biochemical networks aimed to laboratory scientists Tom BMC Systems Biology 2009, 3 :58 (6 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Integrated analysis of DNA copy number and gene expression microarray data using gene sets Renee X Menezes, Marten Boetzer, Melle Sieswerda, Gert-Jan B VAN Ommen, Judith M Boer BMC Bioinformatics 2009, 10 :203 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
Seeking unique and common biological themes in multiple gene lists or datasets: pathway pattern extraction pipeline for pathway-level comparative analysis Ming Yi, Uma Mudunuri, Anney Che, Robert M Stephens BMC Bioinformatics 2009, 10 :200 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
DOTcvpSB, a software toolbox for dynamic optimization in systems biology Tomas Hirmajer, Eva Balsa-Canto, Julio R. Banga BMC Bioinformatics 2009, 10 :199 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Phylogeography of the Alcippe morrisonia (Aves: Timaliidae): long population history beyond late Pleistocene glaciations Gang Song, Yanhua Qu, Zuohua Yin, Shouhsien Li, Naifa Liu, Fumin Lei BMC Evolutionary Biology 2009, 9 :143 (27 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Triangle network motifs predict complexes by complementing high-error interactomes with structural information Bill Andreopoulos, Christof Winter, Dirk Labudde, Michael Schroeder BMC Bioinformatics 2009, 10 :196 (27 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM) Teresa WM Fan, Andrew N Lane, Richard M Higashi, Mohamed A Farag, Hong Gao, Michael Bousamra, Donald M Miller Molecular Cancer 2009, 8 :41 (26 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
iBsu1103: a new genome-scale metabolic model of Bacillus subtilis based on SEED annotations Christopher S Henry, Jenifer F Zinner, Matthew P Cohoon, Rick L Stevens Genome Biology 2009, 10 :R69 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Computational analysis of the interaction between transcription factors and the predicted secreted proteome of the yeast Kluyveromyces lactis Otavio JB Brustolini, Luciano G Fietto, Cosme D Cruz, Flavia ML Passos BMC Bioinformatics 2009, 10 :194 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Modeling the role of p53 pulses in DNA damage induced cell death decision Tingzhe Sun, Chun Chen, Yuanyuan Wu, Shuai Zhang, Jun Cui, Pingping Shen BMC Bioinformatics 2009, 10 :190 (22 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
Marishka K Brown, Yuan Luo BMC Neuroscience 2009, 10 :62 (22 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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