Section Editors

  • Nitin Baliga, Institute for Systems Biology
  • Christina Chan, Michigan State University
  • Luonan Chen, Chinese Academy of Sciences
  • Sang Yup Lee, Korea Advanced Institute of Science and Technology
  • Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
  • Matteo Pellegrini, University of California, Los Angeles

Executive Editor

  • Tim Sands, BioMed Central

Articles

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  • Image attributed to: iStock Photo

    Listening in on cancer cross-talk

    The use of inhibitors to components of cancer signaling pathways is dogged by resistance and cross-talk upregulating compensatory pathways. A new computational framework characterizes the cross-talks between pathways in breast cancer cell lines.

    BMC Systems Biology 2015, 9:2
  • Image attributed to: CDC/Dr. Holdeman

    Predicting C. difficile drug targets

    A highly curated metabolic network model of the bacterium Clostridium difficile, which can cause serious hospital infections, predicts a number of essential genes presenting potential drug targets, some of which have homologs with existing inhibitory drugs.

    BMC Systems Biology 2014, 8:117
  • Image attributed to: Adapted from image by Anthony D'Onofrio, CC BY 2.0

    Compartmentalization in genome-scale models

    An updated model of metabolism and protein expression in E. coli incorporates the role of four sub-cellular compartments, along with a reconstruction of  protein translocation pathways, demonstrates the value of including compartmentalization in models to generate new biological insights

    BMC Systems Biology 2014, 8:110

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Scope

BMC Systems Biology is an open access, peer-reviewed journal that considers articles on experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.

BMC Systems Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.

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Latest supplements

Volume 9 Suppl 1 (21 January 2015)

Selected articles from the Thirteenth Asia Pacific Bioinformatics Conference (APBC 2015): Systems Biology

Proceedings
HsinChu, Taiwan. 21-23 January 2015

Volume 8 Suppl 5 (12 December 2014)

Proceedings of the 25th International Conference on Genome Informatics (GIW/ISCB-Asia): Systems Biology

Research
Tokyo, Japan. 15-17 December 2014

Volume 8 Suppl 4 (8 December 2014)

Thirteenth International Conference on Bioinformatics (InCoB2014): Systems Biology

Research
Sydney, Australia. 31 July - 2 August 2014

View all supplements

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ISSN: 1752-0509