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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Tim Sands PhD
Welcome to BMC Systems Biology published by BioMed Central
BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology (ISSN 1752-0509) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Zoological Record, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Systems Biology 2009, 3 :103
ReTrace finds branching pathways in atom-level representations of genome-scale metabolic networks by considering combinations of the shortest linear pathways, scaling better than constraint-based modeling and avoiding shortfalls of graph-theoretic approaches.
BMC Systems Biology 2009, 3 :97
A Boolean network model for liver cells has four stable system states, two for survival and two for apoptosis, and is validated by successful predictions of the outcome of viral infection and varying growth substrate signals in the presence of FasL.
BMC Systems Biology 2009, 3 :90
The smallest bistable system contains just two reactants and four irreversible reactions, and it reveals that the necessary conditions for bistability are positive feedback, filtering out small stimuli, and a mechanism to prevent 'explosion' of the system.
more info ]
Methodology article
Spectral affinity in protein networks Konstantin Voevodski, Shang-Hua Teng, Yu Xia BMC Systems Biology 2009, 3 :112 (29 [Abstract ] [Provisional PDF ]
Research article
An evaluation of minimal cellular functions to sustain a bacterial cell Yusuke Azuma, Motonori Ota BMC Systems Biology 2009, 3 :111 (28 [Abstract ] [Provisional PDF ]
Research article
Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis Shun-Fu Chen, Yue-Li Juang, Wei-Kang Chou, Jin-Mei Lai, Chi-Ying F Huang, Cheng-Yan Kao, Feng-Sheng Wang BMC Systems Biology 2009, 3 :110 (27 [Abstract ] [Provisional PDF ]
Software
DASMiner: discovering and integrating data from DAS sources Diogo F T Veiga, Helena F Deus, Caner Akdemir, Ana Tereza R Vasconcelos, Jonas S Almeida BMC Systems Biology 2009, 3 :109 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase Carmen Pin, Matthew D Rolfe, Marina Mu BMC Systems Biology 2009, 3 :108 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Long-term prediction of fish growth under varying ambient temperatures using a multiscale dynamic model Nadav S Bar, Nicole Radde BMC Systems Biology 2009, 3 :107 (10 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Using the ratio of means as the effect size measure in combining results of microarray experiments Pingzhao Hu, Celia MT Greenwood, Joseph Beyene BMC Systems Biology 2009, 3 :106 (5 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway in R. sphaeroides Mark AJ Roberts, Elias August, Abdullah Hamadeh, Philip K Maini, Patrick E McSharry, Judith P Armitage, Antonis Papachristodoulou BMC Systems Biology 2009, 3 :105 (31 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
13 C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucosePaula Jouhten, Esa Pitk BMC Systems Biology 2009, 3 :104 (29 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Inferring branching pathways in genome-scale metabolic networks Esa Pitkanen, Paula Jouhten, Juho Rousu BMC Systems Biology 2009, 3 :103 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ] [Cited on BioMed Central ]
Research article
Proteomic analysis of blastema formation in regenerating axolotl limbs Nandini Rao, Deepali Jhamb, Derek J Milner, Bingbing Li, Fengyu Song, Mu Wang, S. Randal Voss, Mathew Palakal, Michael W King, Behnaz Saranjami, Holly LD Nye, Jo Ann Cameron, David L Stocum BMC Biology 2009, 7 :83 (30 [Abstract ] [Provisional PDF ]
Research
Ribosomal protein mRNAs are translationally-regulated
during human dendritic cells activation by LPS
Maurizio Ceppi, Giovanna Clavarino, Evelina Gatti, Enrico Schmidt, Aude de Gassart, Derek Blankenship, Gerald Ogola, Jacques Banchereau, Damien Chaussabel, Philippe Pierre Immunome Research 2009, 5 :5 (27 [Abstract ] [Provisional PDF ]
Research article
ExprAlign - the identification of ESTs in non-model species by alignment of cDNA microarray expression profiles Weizhong Li, Andrew Y Gracey, Luciane Vieira Mello, Andrew Brass, Andrew R Cossins BMC Genomics 2009, 10 :560 (26 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Modeling lymphocytes homing and encounters in lymph nodes Valentina Baldazzi, Paola Paci, Massimo Bernaschi, Filippo Castiglione BMC Bioinformatics 2009, 10 :387 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Regularized estimation of large-scale gene association networks using graphical Gaussian models Nicole Kramer, Juliane Schafer, Anne-Laure Boulesteix BMC Bioinformatics 2009, 10 :384 (24 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Algorithms for effective querying of compound graph-based pathway databases Ugur Dogrusoz, Ahmet Cetintas, Emek Demir, Ozgun Babur BMC Bioinformatics 2009, 10 :376 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Status epilepticus affects the gigantocellular network of the pontine reticular formation P BMC Neuroscience 2009, 10 :133 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord Jean Didier Breton, Pierrick Poisbeau, Pascal Darbon Molecular Pain 2009, 5 :63 (12 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
A generic algorithm for layout of biological networks Falk Schreiber, Tim Dwyer, Kim Marriott, Michael Wybrow BMC Bioinformatics 2009, 10 :375 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Review
Computational models in plant-pathogen interactions: the case of Phytophthora infestans
Andres Pinzon, Emiliano Barreto, Adriana Bernal, Luke Achenie, Andres F Gonzalez Barrios, Raul Isea, Silvia Restrepo Theoretical Biology and Medical Modelling 2009, 6 :24 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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