- Nitin Baliga, Institute for Systems Biology
- Christina Chan, Michigan State University
- Luonan Chen, Chinese Academy of Sciences
- Sang Yup Lee, Korea Advanced Institute of Science and Technology
- Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
- Matteo Pellegrini, University of California, Los Angeles
- Tim Sands, BioMed Central
A highly curated metabolic network model of the bacterium Clostridium difficile, which can cause serious hospital infections, predicts a number of essential genes presenting potential drug targets, some of which have homologs with existing inhibitory drugs.
An updated model of metabolism and protein expression in E. coli incorporates the role of four sub-cellular compartments, along with a reconstruction of protein translocation pathways, demonstrates the value of including compartmentalization in models to generate new biological insights
A new algorithm to calculate elementary flux modes in genome-scale, gives similar speed to existing Double Description approaches but is scalable, and can incorporate additional flux constraints to generate a full subset of EFMs of interest.
A new computation approach to the role of long non-coding RNAs to act as competing endogenous RNAs (miRNA “sponges”) finds that there is a marked rewiring between normal and cancerous breast tissue.
BMC Systems Biology 2014, 8:122
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BMC Systems Biology is an open access, peer-reviewed journal that considers articles on experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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BMC series blog
- 20 November 2014
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- 18 November 2014
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- 06 November 2014
- Behind the image: Kyle Harrington
Volume 8 Suppl 3 (22 October 2014)
Selected articles from the IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2013): Systems Biology Approaches to Biomedicine
Shanghai, China. 18-21 December 2013