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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Tim Sands PhD
Welcome to BMC Systems Biology published by BioMed Central
BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
BMC Systems Biology (ISSN 1752-0509) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Systems Biology 2009, 3 :103
ReTrace finds branching pathways in atom-level representations of genome-scale metabolic networks by considering combinations of the shortest linear pathways, scaling better than constraint-based modeling and avoiding shortfalls of graph-theoretic approaches.
BMC Systems Biology 2009, 3 :97
A Boolean network model for liver cells has four stable system states, two for survival and two for apoptosis, and is validated by successful predictions of the outcome of viral infection and varying growth substrate signals in the presence of FasL.
BMC Systems Biology 2009, 3 :90
The smallest bistable system contains just two reactants and four irreversible reactions, and it reveals that the necessary conditions for bistability are positive feedback, filtering out small stimuli, and a mechanism to prevent 'explosion' of the system.
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Research article
Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase Carmen Pin, Matthew D Rolfe, Marina Munoz-Cuevas, Jay CD Hinton, Michael W Peck, Nicholas J Walton, Jozsef Baranyi BMC Systems Biology 2009, 3 :108 (16 [Abstract ] [Provisional PDF ]
Research article
Long-term prediction of fish growth under varying ambient temperatures using a multiscale dynamic model Nadav S Bar, Nicole Radde BMC Systems Biology 2009, 3 :107 (10 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Using the ratio of means as the effect size measure in combining results of microarray experiments Pingzhao Hu, Celia MT Greenwood, Joseph Beyene BMC Systems Biology 2009, 3 :106 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway in R. sphaeroides Mark AJ Roberts, Elias August, Abdullah Hamadeh, Philip K Maini, Patrick E McSharry, Judith P Armitage, Antonis Papachristodoulou BMC Systems Biology 2009, 3 :105 (31 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
13 C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucosePaula Jouhten, Esa Pitk BMC Systems Biology 2009, 3 :104 (29 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Inferring branching pathways in genome-scale metabolic networks Esa Pitkanen, Paula Jouhten, Juho Rousu BMC Systems Biology 2009, 3 :103 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ] [Cited on BioMed Central ]
Research article
How to identify essential genes from molecular networks? Gabriel del Rio, Dirk Kosch BMC Systems Biology 2009, 3 :102 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments Ramon Grima BMC Systems Biology 2009, 3 :101 (8 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway Richard J Orton, Michiel E Adriaens, Amelie Gormand, Oliver E Sturm, Walter Kolch, David R Gilbert BMC Systems Biology 2009, 3 :100 (5 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Software
An editor for pathway drawing and data visualization in the Biopathways Workbench Robert W Byrnes, Dawn Cotter, Andreia Maer, Joshua Li, David Nadeau, Shankar Subramaniam BMC Systems Biology 2009, 3 :99 (2 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Algorithms for effective querying of compound graph-based pathway databases Ugur Dogrusoz, Ahmet Cetintas, Emek Demir, Ozgun Babur BMC Bioinformatics 2009, 10 :376 (16 [Abstract ] [Provisional PDF ]
Research article
Status epilepticus affects the gigantocellular network of the pontine reticular formation Peter Baracskay, Viola Kiglics, Katalin A. Kekesi, Gabor Juhasz, Andras Czurko BMC Neuroscience 2009, 10 :133 (13 [Abstract ] [Provisional PDF ]
Research
Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord Jean-Didier Breton, Pierrick Poisbeau, Pascal Darbon Molecular Pain 2009, 5 :63 (12 [Abstract ] [Provisional PDF ]
Research article
A generic algorithm for layout of biological networks Falk Schreiber, Tim Dwyer, Kim Marriott, Michael Wybrow BMC Bioinformatics 2009, 10 :375 (12 [Abstract ] [Provisional PDF ]
Review
Computational models in plant-pathogen interactions: the case of Phytophthora infestans
Andres Pinzon, Emiliano Barreto, Adriana Bernal, Luke Achenie, Andres F Gonzalez Barrios, Raul Isea, Silvia Restrepo Theoretical Biology and Medical Modelling 2009, 6 :24 (12 [Abstract ] [Provisional PDF ]
Research article
Linguistic feature analysis for protein interaction extraction Timur Fayruzov, Martine De Cock, Chris Cornelis, Veronique Hoste BMC Bioinformatics 2009, 10 :374 (12 [Abstract ] [Provisional PDF ]
Letter
Sepsis and multiple organ failure represent a chaotic adaptation to severe stress which must be controlled at nanoscale Yusuf Alper Kilic, Ilke Kilic, Mesut Tez Critical Care 2009, 13 :424 (12 [Abstract ] [Full text ] [PDF ]
Methodology article
Illumina WG-6 BeadChip strips should be normalized separately Wei Shi, Ashish Banerjee, Matthew E Ritchie, Steve Gerondakis, Gordon K Smyth BMC Bioinformatics 2009, 10 :372 (11 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Elucidation of functional consequences of signalling pathway interactions Adaoha E C Ihekwaba, Phuong T Nguyen, Corrado Priami BMC Bioinformatics 2009, 10 :370 (6 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal children Bj Proteome Science 2009, 7 :40 (2 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
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