Section Editors
- Nitin Baliga, Institute for Systems Biology
- Christina Chan, Michigan State University
- Luonan Chen, Chinese Academy of Sciences
- Sang Yup Lee, Korea Advanced Institute of Science and Technology
- Matteo Pellegrini, University of California, Los Angeles
Executive Editor
- Tim Sands, BioMed Central
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Articles
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BMC Systems Biology 2012, 6:138Model of ER dependent gene expression
A minimal mechanistic model of estrogen receptor alpha-dependent gene expression, predicts complex non-linear effects in transcriptional response to natural hormone 17 beta-estradiol and its external competitor tamoxifen under a range of biologically plausible parameter values.
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BMC Systems Biology 2012, 6:134From improved codon usage to increased expression
A novel method for codon usage optimization in artificial gene synthesis, optimizing use of both individual codon usage and codon context approaches, is predicted to lead to improved in vitro heterologous protein expression in biotechnology applications.
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BMC Systems Biology 2012, 6:133R package for signaling network training
CellNOptR is an R based software package for the training of signaling networks extracted from prior knowledge using experimental data, which extends the existing CellNetOptimizer MATLAB package with further logical formalisms.
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BMC Systems Biology 2012, 6:126Wiring genetic NAND/NOR gates
A novel genetic circuit is proposed and computationally tested that can be dynamically reconfigured to serve as either a NAND or NOR genetic logic gate in either single cells or cell populations.
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Research article
Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT
BMC Systems Biology 2013, 7:3
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Scope
BMC Systems Biology is an open access, peer-reviewed journal that considers articles on experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.
It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.
BMC series blog
- 01 March 2013
- Bionanotechnology in BMC Biochemistry
- 27 February 2013
- BMC Psychology officially launches!
Latest supplements
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The International Conference on Intelligent Biology and Medicine (ICIBM): Systems Biology
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Nashville, TN, USA. 22-24 April 2012
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Proceedings of the 23rd International Conference on Genome Informatics (GIW 2012)
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Tainan, Taiwan. 12-14 December 2012
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