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	1. 713 Accesses	Research article Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking sub-site C6 Lalitha Venkatramani, Eric S Johnson, Gundarao Kolavi, Gillian M Air, Wayne J Brouillette, Blaine HM Mooers BMC Structural Biology 2012, 12:7 (6 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The crystal structure of a novel benzoic acid inhibitor of influenza neuraminidase reveals an increased number of contacts compared to previous inhibitors, due to a tilt in the position of the benzene ring that maximizes these interactions.
	2. 629 Accesses	Commentary Reliable structural interpretation of small-angle scattering data from bio-molecules in solution - the importance of quality control and a standard reporting framework David A Jacques, Jules M Guss, Jill Trewhella BMC Structural Biology 2012, 12:9 (17 May 2012) Abstract \| Provisional PDF \| PubMed \| 1 comment \| Editor’s summary Jill Trewhella and colleagues describe the rationale behind guidelines recently issued by The International Union of Crystallography for the reporting of biomolecular structures derived from Small-Angle Scattering (SAS) data.
	3. 599 Accesses	Research article The Ramachandran plots of glycine and pre-proline Bosco K Ho, Robert Brasseur BMC Structural Biology 2005, 5:14 (16 August 2005) Abstract \| Full text \| PDF \| PubMed
	4. 469 Accesses	Research article Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins Lakshmipuram S Swapna, Swapnil Mahajan, Alexandre de Brevern, Narayanaswamy Srinivasan BMC Structural Biology 2012, 12:6 (3 May 2012) Abstract \| Provisional PDF \| PubMed
	5. 416 Accesses	Research article Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding Wei Qiu, Aiping Dong, Juan C Pizarro, Alexei Botchkarsev, Jinrong Min, Amy K Wernimont, Tanya Hills, Raymond Hui, Jennifer D Artz BMC Structural Biology 2012, 12:2 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural characterization of peroxiredoxins from Plasmodium species identifies the novel toroid octameric oligomer of PyTrx-Px1 and confirms that PvTrx-Px1 is a hydrogen peroxide-sensitive peroxiredoxin, which may aid targeting of these antioxidant enzymes in drug design
	6. 381 Accesses	Research article Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface Alessandro Siglioccolo, Alessandro Paiardini, Maria Piscitelli, Stefano Pascarella BMC Structural Biology 2011, 11:50 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	7. 376 Accesses	Research article Are different stoichiometries feasible for complexes between lymphotoxin-alpha and tumor necrosis factor receptor 1? Nahren M Mascarenhas, Johannes Kästner BMC Structural Biology 2012, 12:8 (8 May 2012) Abstract \| Provisional PDF \| PubMed
	8. 365 Accesses	Research article A transcriptional-switch model for Slr1738-controlled gene expression in the cyanobacterium Synechocystis Paul Garcin, Olivier Delalande, Ju-Yuan Zhang, Corinne Cassier-Chauvat, Franck Chauvat, Yves Boulard BMC Structural Biology 2012, 12:1 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A 3D structure of the complex between the PerR-like regulator Slr1738 and its target DNA, which controls metal and oxidative stress response in the cyanobaterium Synechocystis, provides insight into stability and recognition in protein-DNA interactions
	9. 328 Accesses	Research article Exploring functionally related enzymes using radially distributed properties of active sites around the reacting points of bound ligands Keisuke Ueno, Katsuhiko Mineta, Kimihito Ito, Toshinori Endo BMC Structural Biology 2012, 12:5 (26 April 2012) Abstract \| Provisional PDF \| PubMed
	10. 287 Accesses	Research article Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics Wataru Nemoto, Hiroyuki Toh BMC Structural Biology 2012, 12:11 (29 May 2012) Abstract \| Provisional PDF \| PubMed
	11. 281 Accesses	Research article Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine Matthieu Schapira, Ruben Abagyan, Maxim Totrov BMC Structural Biology 2002, 2:1 (18 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	12. 256 Accesses	Research article Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1 Julio C Silva, Julio C Borges, Douglas M Cyr, Carlos HI Ramos, Iris L Torriani BMC Structural Biology 2011, 11:40 (19 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Deletion of the central ZFLR-CTDI domain in the Hsp40 protein Ydj1 changes the relative position of the J-domain, suggesting that interactions between these domains are important in determining the unique quaternary structure of Type I Hsp40s
	13. 250 Accesses	Research article Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules Plínio Delatorre, Bruno AM Rocha, Emmanuel P Souza, Taianá M Oliveira, Gustavo A Bezerra, Frederico BMB Moreno, Beatriz T Freitas, Tatiane Santi-Gadelha, Alexandre H Sampaio, Walter F Azevedo, Benildo S Cavada BMC Structural Biology 2007, 7:52 (2 August 2007) Abstract \| Full text \| PDF \| PubMed
	14. 242 Accesses	Research article Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle Gerhard Schenk, Tristan W Elliott, Eleanor Leung, Lyle E Carrington, Nataša Mitić, Lawrence R Gahan, Luke W Guddat BMC Structural Biology 2008, 8:6 (31 January 2008) Abstract \| Full text \| PDF \| PubMed
	15. 242 Accesses	Research article Modeling structure and flexibility of Candida antarctica lipase B in organic solvents Peter Trodler, Jürgen Pleiss BMC Structural Biology 2008, 8:9 (6 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	16. 241 Accesses	Research article An in silico study of the molecular basis of B-RAF activation and conformational stability Filip F Fratev, Svava Jónsdóttir BMC Structural Biology 2009, 9:47 (22 July 2009) Abstract \| Full text \| PDF \| PubMed
	17. 240 Accesses	Research article Natural history of S-adenosylmethionine-binding proteins Piotr Z Kozbial, Arcady R Mushegian BMC Structural Biology 2005, 5:19 (14 October 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of the phyletic distribution and structural similarities of S-adenosylmethionine-binding proteins indicate that two widespread folds, the Rossman fold and TIM barrel, have repeatedly evolved for diverse types of reactions that require S-adenosylmethionine.
	18. 221 Accesses	Research article Crystal structural analysis of human serum albumin complexed with hemin and fatty acid Patricia A Zunszain, Jamie Ghuman, Teruyuki Komatsu, Eishun Tsuchida, Stephen Curry BMC Structural Biology 2003, 3:6 (7 July 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The structure of a human serum albumin-hemin-myristate complex reveals a new conformation plus key polar and hydrophobic interactions that should be useful in designing HSA-heme complexes with modified oxygen-binding properties.
	19. 214 Accesses	Research article A structural model of the E. coli PhoB Dimer in the transcription initiation complex Chang-Shung Tung, Benjamin H McMahon BMC Structural Biology 2012, 12:3 (20 March 2012) Abstract \| Full text \| PDF \| PubMed
	20. 203 Accesses	Correction Correction: Prediction and analysis of the modular structure of cytochrome P450 monooxygenases Demet Sirim, Michael Widmann, Florian Wagner, Jurgen Pleiss BMC Structural Biology 2012, 12:4 (25 April 2012) Abstract \| Provisional PDF \| PubMed
	21. 195 Accesses	Research article The Host-Pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains Sara MØ Solbak, Victor Wray, Ole Horvli, Arnt J Raae, Marte I Flydal, Petra Henklein, Peter Henklein, Manfred Nimtz, Ulrich Schubert, Torgils Fossen BMC Structural Biology 2011, 11:49 (20 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Identification of a region of HIV-1 Vpr which binds specifically to the host cellular factor CypA with similar affinity to full-length Vpr is the first such binding domain described that involves no proline residues.
	22. 176 Accesses	Software LIGSITE^csc: predicting ligand binding sites using the Connolly surface and degree of conservation Bingding Huang, Michael Schroeder BMC Structural Biology 2006, 6:19 (24 September 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 175 Accesses	Research article Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study Swadha Anand, Debasisa Mohanty BMC Structural Biology 2012, 12:10 (28 May 2012) Abstract \| Provisional PDF \| PubMed
	24. 166 Accesses	Research article The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2) Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga, John Kuriyan BMC Structural Biology 2009, 9:7 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The tyrosine-kinase inhibitor imatinib is revealed by X-ray crystallography to occupy the active site of the oxidoreductase NQO2, a secondary target whose inhibition may be responsible for side effects in leukaemia patients receiving treatment with the drug.
	25. 164 Accesses	Research article Structural analysis of heme proteins: implications for design and prediction Ting Li, Herbert L Bonkovsky, Jun-tao Guo BMC Structural Biology 2011, 11:13 (3 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Heme binding pockets provide a hydrophobic environment for the heme ring structure, being enriched in aromatic and non-polar amino acids, with most heme proteins undergoing small conformational changes after heme binding.