- James Chou, Harvard Medical School
- Jianping Ding, Shanghai Institutes of Biological Sciences
- Jean-Luc Pellequer, CEA Marcoule
- Paul A Ramsland, Macfarlane Burnet Institute for Medical Research and Public Health
- Catherine Potenski, BioMed Central
The crystal structure of nucleoside diphosphate kinase from the parasite L. braziliensis provides reveals a partially unfolded C-terminus that could serve as a potential target for drug therapies.
Molecular modeling of the recognition and modification of histones by the oncogenic NSD class of histone methyl transferases sheds light on the dynamics of these interactions, potentially aiding the design of inhibitors for chemotherapies.
The structure of polymyxin B resistance protein D from E. coli reveals distinct features differing from those of closely related species that may help determine its mechanisms of antibiotic resistance.
The Gluconacetobacter diazotrophicus enzyme responsible for breaking down pyruvate into acetaldehyde and carbon dioxide, an important intermediate step in the production of ethanol, is structurally similar to pyruvate decarboxylases from other bacterial species.
Effects of extreme environments, such as high temperature and high pressure, on protein conformation were examined using molecular dynamics simulations, providing insight into the mechanisms of adaptations to deep water conditions in archaea.
BMC Structural Biology 2014, 14:23
BMC Structural Biology is an open access, peer-reviewed journal that considers articles on investigations into the structure of biological macromolecules, including solving structures, structural and functional analyses, and computational modeling.
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Section Editor's profile
Dr Ramsland is currently the Sir Zelman Cowen Fellow and a Group Leader in the Centre for Immunology at the Burnet Institute (Melbourne, Australia). His research examines the diverse structural roles of carbohydrates and glycoproteins in immunity and infection (Structural Glycobiology) using crystallography, computational modelling, automated docking and solution scattering techniques. He has over 90 scientific publications including primary research papers, reviews/chapters and has recently co-edited a book on Structural Glycobiology.
"Together with Dr Cy Jeffries, Deputy Section Editor, I am pleased to be involved in guiding the development of the Small-Angle Scattering section of BMC Structural Biology. This new section incorporates all aspects of the structural analysis of biological macromolecules using techniques in small-angle scattering including but not limited to: studies incorporating substantial analysis by small-angle X-ray scattering and/or neutron scattering."