- James Chou, Harvard Medical School
- Jianping Ding, Shanghai Institutes of Biological Sciences
- Jean-Luc Pellequer, CEA Marcoule
- Paul A Ramsland, Macfarlane Burnet Institute for Medical Research and Public Health
- Torsten Schwede, Biozentrum Univ. of Basel, SIB Swiss Institute of Bioinformatics
- Catherine Potenski, BioMed Central
The Gluconacetobacter diazotrophicus enzyme responsible for breaking down pyruvate into acetaldehyde and carbon dioxide, an important intermediate step in the production of ethanol, is structurally similar to pyruvate decarboxylases from other bacterial species.
Effects of extreme environments, such as high temperature and high pressure, on protein conformation were examined using molecular dynamics simulations, providing insight into the mechanisms of adaptations to deep water conditions in archaea.
A new model incorporates high resolution structural data from a recently crystallyzed initiation factor to elucidate the direct interactions between initiator tRNA and domain IV of eIF5B in the context of the yeast 80S ribosome.
Structural characterization of the ANKS3-SAM/ANKS6-SAM complex reveals that a R823W point mutation causes destabilization of the SAM domain, a mechanism which is implicated in the pathogenesis of polycystic kidney disease.
Crystal packing of the spin labelled crystal structure of azurin provides a useful input model for evaluating two popular in silico spin labelling programs, highlighting potential limitations of the algorithms.
BMC Structural Biology 2014, 14:23
BMC Structural Biology is an open access, peer-reviewed journal that considers articles on investigations into the structure of biological macromolecules, including solving structures, structural and functional analyses, and computational modeling.
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Section Editor's profile
Dr Ramsland is currently the Sir Zelman Cowen Fellow and a Group Leader in the Centre for Immunology at the Burnet Institute (Melbourne, Australia). His research examines the diverse structural roles of carbohydrates and glycoproteins in immunity and infection (Structural Glycobiology) using crystallography, computational modelling, automated docking and solution scattering techniques. He has over 90 scientific publications including primary research papers, reviews/chapters and has recently co-edited a book on Structural Glycobiology.
"Together with Dr Cy Jeffries, Deputy Section Editor, I am pleased to be involved in guiding the development of the Small-Angle Scattering section of BMC Structural Biology. This new section incorporates all aspects of the structural analysis of biological macromolecules using techniques in small-angle scattering including but not limited to: studies incorporating substantial analysis by small-angle X-ray scattering and/or neutron scattering."