Major structural role for PHP domain

Metal binding can be restored to E. coli polymerase III PHP domain with only three point mutations, demonstrating that the domain structure is highly conserved and is a major structural element of this bacterial replicative polymerase.

Ligand-centric protein annotation

A new systematic approach for grouping protein structures based upon the type and conformation of the ligand they bind to reveals some unexpected findings and extends the existing structural classification of S-adenosyl-L-13 methionine (SAM) binding proteins

Unique role for Cys6.47 in class A GPCRs

Analysis of G protein-coupled receptor (GPCR) crystal structures and molecular dynamics simulations of model peptides suggests Cys6.47 is the gate keeper of a hydrogen bond network involving residues known to be crucial to receptor activation.

Conformational changes in FPPS complex

Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.

Modeling macromolecules with nano-objects

Protein Nano-Object Integrator (ProNOI) is a novel software tool for generating atomic-style nano shapes in conjunction with biological macromolecules, allowing users to manipulate shape, dimension and position, and charge objects with user-specified charge density.