- James Chou, Harvard Medical School
- Jianping Ding, Shanghai Institutes of Biological Sciences
- Jean-Luc Pellequer, CEA Marcoule
- Paul A Ramsland, Macfarlane Burnet Institute for Medical Research and Public Health
- Catherine Potenski, BioMed Central
Molecular dynamic simulations of the hexameric UreI transporter from Helicobacter pylori reveal pH-dependent conformational changes driven by periplasmic loop interactions.
The vaccinia virus DNA repair enzyme that removes uracil from DNA, uracil-DNA glycosylase D4, binds to undamaged DNA, with two subunits simultaneously binding to complementary strands.
Computation analysis identifies six main regions in amyloid proteins that are responsible for their aggregate formation and shows that mutating certain residues can destabilize these amyloid fibers.
Co-variation in amino acid sequence of intramolecular interaction pairs can be used for structural prediction and classification of unknown transmembrane proteins.
The crystal structure of the DNA polymerase III beta subunit from Deinococcus radiodurans sheds light on the mechanisms of efficient DNA metabolism that enable this bacterium to survive high doses of radiation.
BMC Structural Biology 2015, 15:10
BMC Structural Biology is an open access, peer-reviewed journal that considers articles on investigations into the structure of biological macromolecules, including solving structures, structural and functional analyses, and computational modeling.
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Section Editor's profile
Dr Ramsland is currently the Sir Zelman Cowen Fellow and a Group Leader in the Centre for Immunology at the Burnet Institute (Melbourne, Australia). His research examines the diverse structural roles of carbohydrates and glycoproteins in immunity and infection (Structural Glycobiology) using crystallography, computational modelling, automated docking and solution scattering techniques. He has over 90 scientific publications including primary research papers, reviews/chapters and has recently co-edited a book on Structural Glycobiology.
"Together with Dr Cy Jeffries, Deputy Section Editor, I am pleased to be involved in guiding the development of the Small-Angle Scattering section of BMC Structural Biology. This new section incorporates all aspects of the structural analysis of biological macromolecules using techniques in small-angle scattering including but not limited to: studies incorporating substantial analysis by small-angle X-ray scattering and/or neutron scattering."