Articles

Volume 9 (2009) - January 2009

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Research article   Open Access

Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus

John Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova, Andrew I Su BMC Chemical Biology 2009, 9:2 (16 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

Patrick Chène, Joëlle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz, Thomas Radimerski BMC Chemical Biology 2009, 9:1 (7 January 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The discovery of a novel catalytic inhibitor of human topoisomerase II ATPase activity, quinonoline aminopurine compound 1 (QAP1), demonstrates the potential for the development of anti-cancer drugs utilizing this mechanism.