Volume 10 (2010) - February 2010
Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy, Charles Brenner BMC Chemical Biology 2010, 10:2 (22 February 2010)
Quantifying the NAD+ metabolome in two different conditions that extend yeast lifespan indicates that NAD+ precursor vitamins and calorie restriction may extend lifespan by different mechanisms and that ratios of NAD+ metabolites may not underlie the mechanism of calorie restriction.
Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf, William S Saunders BMC Chemical Biology 2010, 10:1 (11 February 2010)
Non-cancer cell lines escape mitotic arrest after treatment with the anti-tubulin agent, disorazole C1, in a cyclin-B-dependent and p53-independent manner, but cancer cell lines undergo apoptosis, indicating that this compound might have therapeutic potential to treat cancer.