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76.
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Combined use of steady-state fluorescence emission and anisotropy of merocyanine 540 to distinguish crystalline, gel, ripple, and liquid crystalline phases in dipalmitoylphosphatidylcholine bilayers
Hannabeth A Franchino, Brett C Johnson, Steven K Neeley, Rajeev B Tajhya, Mai P Vu, Heather A Wilson-Ashworth, John D Bell PMC Biophysics 2010, 3:14 (5 November 2010)
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77.
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Conformational preference of ChaK1 binding peptides: a molecular dynamics study
Jiajing Zhang, Christopher A King, Kevin Dalby, Pengyu Ren PMC Biophysics 2010, 3:2 (24 March 2010)
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Editor’s summary
In this work we explored possible kinase-substrate binding modes and the likelihood of an alpha-helix docking interaction, within a kinase active site, using molecular modeling. The simulations indicate that the two substrate peptides are unlikely to bind and react with the ChaK1 kinase in a stable alpha-helical conformation overall.
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Nanoscopy of the cellular response to hypoxia by means of fluorescence resonance energy transfer (FRET) and new FRET software
Christoph Wotzlaw, Silke Gneuss, Rebecca Konietzny, Joachim Fandrey PMC Biophysics 2010, 3:5 (5 March 2010)
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Fluorescence resonance energy transfer (FRET) was established to determine the assembly of the Hypoxia-Inducible-Factor-1 complex and to study the interaction of the alpha-subunit of HIF-1 with O2-sensing hydroxylase. New software was developed to improve the quality and reliability of FRET measurements.
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79.
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Membrane protein dynamics: limited lipid control
Balázs Szalontai PMC Biophysics 2009, 2:1 (6 February 2009)
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Editor’s summary
Correlation of lipid disorder with membrane protein dynamics has been studied with infrared spectroscopy, by combining data characterizing lipid phase, protein structure and, via hydrogen-deuterium exchange, protein dynamics. In all membranes studied, dynamics seemed to be governed by lipids around the low-temperature limit, and by proteins around the high-temperature limit of membrane functionality.
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80.
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Combined molecular dynamics and continuum solvent studies of the pre-pore Cry4Aa trimer suggest its stability in solution and how it may form pore
Taveechai Taveecharoenkool, Chanan Angsuthanasombat, Chalermpol Kanchanawarin PMC Biophysics 2010, 3:10 (13 May 2010)
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Cry4Aa toxin is one of the mosquito-larvicidal proteins produced by Bacillus thuringiensis, and is thought to form lethal trimeric pores in the larval gut membrane. A full-atomic pre-pore structure of the Cry4Aa trimer reveals that Cry4Aa toxin uses the amino acid residues on alpha-helices 3, 4 and 6 to form trimer.
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Monte Carlo Simulations indicate that Chromati: Nanostructure is accessible by Light Microscopy
Philipp M Diesinger, Dieter W Heermann PMC Biophysics 2010, 3:11 (10 June 2010)
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Editor’s summary
In this work we determine the radial pair distribution function of chromatin described by our E2A model and find that the dominant peaks which characterize the chromatin structure are very robust in several ways: They can still be identified in the case of chromatin fibers with reasonable linker histone and nucleosome defect rates as well as in the 2D case after a projection like in most high-res light microscopy experiments.
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82.
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Bistability in the actin cortex
Carsten Beta PMC Biophysics 2010, 3:12 (24 June 2010)
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Editor’s summary
Multi-color fluorescence imaging experiments of wave forming Dictyostelium cells have revealed that actin waves separate two domains of the cell cortex that differ in their actin structure and phosphoinositide composition. We propose a bistable model of actin dynamics to account for these experimental observation.
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83.
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Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruzi ribosomal P proteins and their interaction with a monoclonal antibody structural model
Osvaldo A Martín, Myriam E Villegas, Carlos F Aguilar PMC Biophysics 2009, 2:4 (27 May 2009)
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Editor’s summary
This work describes clearly the interactions of the structural elements involved in the autoimmune mechanism of anti-P auto-antibodies cross-reaction and stimulation of the beta1-adrenoreceptor and the visual pigment rhodopsin in the heart. Results from this study could lead eventually to the development of treatments to abolish receptor mediated symptoms in Chagas' disease.
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