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	26. 66 Accesses	Research article Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane Steven C Nelson, Steven K Neeley, Eric D Melonakos, John D Bell, David D Busath BMC Biophysics 2012, 5:5 (24 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Steady-state anisotropy of two fluorescent probes at different depths in a lipid bilayer reveals a decrease in anisotropy with increasing isoflurane anesthetic concentration, reflecting changes in the lateral pressure profile of the membrane.
	27. 63 Accesses	Research article Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins Anna Maniccia, Wei Yang, Julian A Johnson, Shunyi Li, Harianto Tjong, Huan-Xiang Zhou, Lev A Shaket, Jenny J Yang PMC Biophysics 2009, 2:11 (21 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We report a systematic investigation of the role of local charge number and type of coordination residues in Ca2+ binding and protein stability, and observe a striking tradeoff between Ca2+/Ln3+ affinity and protein stability when the net charge of the coordination residues is varied.
	28. 63 Accesses	Research article The influence of membrane physical properties on microvesicle release in human erythrocytes Laurie J Gonzalez, Elizabeth Gibbons, Rachel W Bailey, Jeremy Fairbourn, Thaothanh Nguyen, Samantha K Smith, Katrina B Best, Jennifer Nelson, Allan M Judd, John D Bell PMC Biophysics 2009, 2:7 (24 August 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Exposure of human erythrocytes to elevated intracellular calcium causes fragments of the cell membrane to be shed as microvesicles. This study tested the hypothesis that microvesicle release depends on microscopic membrane physical properties such as lipid order, fluidity, and composition.
	29. 63 Accesses	Methodology article Time-resolved force distribution analysis Bogdan I Costescu, Frauke Gräter BMC Biophysics 2013, 6:5 (1 May 2013) Abstract \| Provisional PDF
	30. 58 Accesses	Research article Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms Daniel Neumann, Johanna Bückers, Lars Kastrup, Stefan W Hell, Stefan Jakobs PMC Biophysics 2010, 3:4 (5 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The voltage-dependent anion channel (VDAC, also known as mitochondrial porin) is the major transport channel mediating the transport of metabolites, including ATP, across the mitochondrial outer membrane. In this study we show that whereas hVDAC1 and hVDAC2 are localized predominantly within the same distinct domains in the outer membrane, hVDAC3 is mostly uniformly distributed over the surface of the mitochondrion.
	31. 60 Accesses	Research article Arbitrary protein−protein docking targets biologically relevant interfaces Juliette Martin, Richard Lavery BMC Biophysics 2012, 5:7 (6 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Docking of target proteins against an arbitrary set of partners generally leads to non-random localization of interaction interfaces as the false complexes favor residues from true interaction sites, allowing prediction of biologically relevant protein interfaces
	32. 57 Accesses	Research article Mechanism of PhosphoThreonine/Serine Recognition and Specificity for Modular Domains from All-atom Molecular Dynamics Yu-ming M Huang, Chia-en A Chang BMC Biophysics 2011, 4:12 (25 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mechanism of phosphothreonine/serine recognition and specificity is elucidated for three well-known phosphopeptide-binding domains important for signal transduction: BRCT repeats, WW domain and forkhead-associated domain (FHA) with the use of molecular dynamics simulations.
	33. 57 Accesses	Research article Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation Yue Hou, Sarah Hedberg, Ian C Schneider BMC Biophysics 2012, 5:8 (11 May 2012) Abstract \| Full text \| PDF \| PubMed
	34. 56 Accesses	Research article ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations Muhammad S Ahmad, Bushra Mirza, Mukhtiar Hussain, Muhammad Hanif, Saqib Ali, Michael J Walsh, Francis L Martin PMC Biophysics 2008, 1:3 (5 November 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. This work shows that IR spectra, derived following ATR-FTIR spectroscopy, from organotin-treated MCF-7 cells exhibit molecular alterations following low-dose exposures. This approach highlights the potential applicability of mid-IR spectroscopy to signature toxic effects at sub-lethal concentrations following typical environmental exposures to environmental contaminants.
	35. 56 Accesses	Research article Brownian dynamics simulation of analytical ultracentrifugation experiments AI Díez, A Ortega, J Garcia de la Tore BMC Biophysics 2011, 4:6 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using Brownian dynamics to simulate the trajectories of the particles could lead to improved and efficient predictions of time-dependent concentration profiles during analytical ultracentrifugation experiments.
	36. 56 Accesses	Software APM_GUI: analyzing particle movement on the cell membrane and determining confinement Silvia A Menchón, Mauricio G Martín, Carlos G Dotti BMC Biophysics 2012, 5:4 (20 February 2012) Abstract \| Full text \| PDF \| PubMed
	37. 54 Accesses	Research article Flexibility of EF-hand motifs: structural and thermodynamic studies of Calcium Binding Protein-1 from Entamoeba histolytica with Pb²⁺, Ba²⁺, and Sr²⁺ Shivesh Kumar, Ejaz Ahmad, Sanjeev Kumar, Rizwan Khan, Samudrala Gourinath BMC Biophysics 2012, 5:15 (20 August 2012) Abstract \| Full text \| PDF \| PubMed
	38. 53 Accesses	Research article Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences Rasha Bassam, Ilya Digel, Juergen Hescheler, Ayseguel Temiz Artmann, Gerhard M Artmann BMC Biophysics 2013, 6:1 (4 January 2013) Abstract \| Full text \| PDF \| PubMed
	39. 52 Accesses	Research article An effective all-atom potential for proteins Anders Irbäck, Simon Mitternacht, Sandipan Mohanty PMC Biophysics 2009, 2:2 (8 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We describe and test an implicit solvent all-atom potential for simulations of protein folding and aggregation. The potential is developed through studies of structural and thermodynamic properties of 17 peptides with diverse secondary structure.
	40. 53 Accesses	Research article Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data Mizuki Morita, AVSK Katta, Shandar Ahmad, Takaharu Mori, Yuji Sugita, Kenji Mizuguchi BMC Biophysics 2011, 4:21 (14 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tightly-bound lipid molecules and lipids in the annular shell interact with membrane proteins in a similar manner, largely explained by general lipophilicity, that suggests a common pattern of lipid tail-amino acid interactions
	41. 53 Accesses	Research article Membrane microdomains emergence through non-homogeneous diffusion Hédi A Soula, Antoine Coulon, Guillaume Beslon BMC Biophysics 2012, 5:6 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Non-homogeneous diffusion in cell membranes leads to the formation of protein/ lipid enriched microdomains in a model of membrane dynamics, with domains of high viscosity tending to gather a statistically larger proportion of diffusive particles
	42. 52 Accesses	Research article Effects of spermine NONOate and ATP on the thermal stability of hemoglobin Rasha Bassam, Juergen Hescheler, Ayseguel Temiz-Artmann, Gerhard M Artmann, Ilya Digel BMC Biophysics 2012, 5:16 (28 August 2012) Abstract \| Full text \| PDF \| PubMed
	43. 50 Accesses	Research article Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding Alexandra M Person, Gregg B Wells BMC Biophysics 2011, 4:19 (23 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Manipulation of maximum ligand and receptor concentrations and intentionally increasing ligand depletion are potentially helpful approaches to study low affinity binding of epibatidine to an independent binding site of alpha4beta2 nicotinic acetylcholine receptor.
	44. 51 Accesses	Research article Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII Lina Baranauskienė, Daumantas Matulis BMC Biophysics 2012, 5:12 (7 June 2012) Abstract \| Full text \| PDF \| PubMed
	45. 50 Accesses	Commentary Intracellular chemical gradients: morphing principle in bacteria Robert G Endres BMC Biophysics 2012, 5:18 (7 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Robert Endres discusses a new study in BMC Biophysics that supports the emerging view that intracellular chemical gradients can exist in bacterial cells, and how these may limit in vitro analyses.
	46. 47 Accesses	Methodology article A Bayesian method for inferring quantitative information from FRET data Catherine A Lichten, Peter S Swain BMC Biophysics 2011, 4:10 (9 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new Bayesian algorithm is available for extracting quantitative information on molecular interactions from FRET (Forster resonance energy transfer) data which yields both an estimate of the dissociation constant and the uncertainty associated with that estimate.
	47. 46 Accesses	Research article Spindles and active vortices in a model of confined filament-motor mixtures David A Head, WJ Briels, Gerhard Gompper BMC Biophysics 2011, 4:18 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A discrete filament-motor protein model of subcellular microtubule self-assembly in fission yeast spontaneously generates a number of steady states, including spindles, nematics, and asters, highlighting potential mechanisms for self-organisation in filaments
	48. 44 Accesses	Research article Physical constraints on the establishment of intracellular spatial gradients in bacteria Carolina Tropini, Naveed Rabbani, Kerwyn Huang BMC Biophysics 2012, 5:17 (29 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	49. 42 Accesses	Research article Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells Erik S Welf, Ulhas P Naik, Babatunde A Ogunnaike BMC Biophysics 2011, 4:15 (9 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cells can sense the availability of extracellular matrix binding sites and in response they regulate the sizes, shapes, and locations of integrin clusters that mediate cell adhesion to surrounding tissues.
	50. 42 Accesses	Research article A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction Jorge L Barreda, Huan-Xiang Zhou BMC Biophysics 2011, 4:5 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analytical solution to modeling the diffusion and reaction of acetylcholine in a neuromuscular junction and the binding of Ca2+ in a dyadic cleft provides a unique benchmark for testing numerical modeling methods.