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	1. 711 Accesses	Correspondence Can dietary fibre help provide safer food products for sufferers of gluten intolerance? A well-established biophysical probe may help towards providing an answer M Samil Kök, Richard Gillis, Shirley Ang, David Lafond, Arthur S Tatham, Gary Adams, Stephen E Harding BMC Biophysics 2012, 5:10 (17 May 2012) Abstract \| Provisional PDF \| PubMed \| 1 comment \| Editor’s summary Stephen Harding and colleagues speculate on the role that the ultracentrifuge assay procedure could play in detecting non-toxic biopolymers capable of sequestering ingested gluten peptides, with the eventual aim of reducing gluten intolerance symptoms.
	2. 628 Accesses	Research article Arbitrary protein-protein docking targets biologically relevant interfaces Juliette Martin, Richard Lavery BMC Biophysics 2012, 5:7 (6 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Docking of target proteins against an arbitrary set of partners generally leads to non-random localization of interaction interfaces as the false complexes favor residues from true interaction sites, allowing prediction of biologically relevant protein interfaces
	3. 436 Accesses	Research article Membrane microdomains emergence through non-homogeneous diffusion Hedi A Soula, Antoine Coulon, Guillaume Beslon BMC Biophysics 2012, 5:6 (30 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Non-homogeneous diffusion in cell membranes leads to the formation of protein/ lipid enriched microdomains in a model of membrane dynamics, with domains of high viscosity tending to gather a statistically larger proportion of diffusive particles
	4. 395 Accesses	Software DelPhi: a comprehensive suite for DelPhi software and associated resources Lin Li, Chuan Li, Subhra Sarkar, Jie Zhang, Shawn Witham, Zhe Zhang, Lin Wang, Nicholas Smith, Marharyta Petukh, Emil Alexov BMC Biophysics 2012, 5:9 (14 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The DelPhi package is a comprehensive and user-friendly suite of tools for modelling electrostatic potentials in macromolecules using the Poisson-Boltzmann Equation, and is now enriched with additional features for greater usability.
	5. 359 Accesses	Research article Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation Yue Hou, Sarah Hedberg, Ian C Schneider BMC Biophysics 2012, 5:8 (11 May 2012) Abstract \| Provisional PDF \| PubMed
	6. 256 Accesses	Mini-review The multiple faces of self-assembled lipidic systems Guillaume Tresset PMC Biophysics 2009, 2:3 (17 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary From the plasma membrane of archaebacteria to gene delivery, self-assembled lipidic systems have left their mark in cell biology and nanobiotechnology; however, the underlying physics is yet to be fully unraveled.
	7. 204 Accesses	Research article Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations Haina Qin, Liangzhong Lim, Jianxing Song BMC Biophysics 2012, 5:2 (25 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Structural determination of the EphA4 ligand binding domain provides the first experimental and computational evidence that intrinsic dynamics are most likely to be responsible for the observed high conformational diversity that mediates binding affinity and specificity.
	8. 194 Accesses	Research article Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane Steven C Nelson, Steven K Neeley, Eric D Melonakos, John D Bell, David D Busath BMC Biophysics 2012, 5:5 (24 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Steady-state anisotropy of two fluorescent probes at different depths in a lipid bilayer reveals a decrease in anisotropy with increasing isoflurane anesthetic concentration, reflecting changes in the lateral pressure profile of the membrane.
	9. 170 Accesses	Editorial Diffusion and association processes in biological systems: theory, computation and experiment Paolo Mereghetti, Daria Kokh, J Andrew McCammon, Rebecca C Wade BMC Biophysics 2011, 4:2 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rebecca Wade and colleagues provide a snapshot of research from a thematic series of articles on biological diffusion and Brownian dynamics simulations, which highlights a vibrant research field with growing synergy between experimental and computational studies.
	10. 160 Accesses	Research article Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis, Dimitrios Morikis BMC Biophysics 2012, 5:3 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The spatial distributions of electrostatic potentials and charges in the V3 loop of HIV-1 protein gp120 may be responsible for both long- and short-range interactions with co-receptors, ultimately affecting viral entry into cells
	11. 148 Accesses	Review Diffusion in crowded biological environments: applications of Brownian dynamics Maciej Długosz, Joanna Trylska BMC Biophysics 2011, 4:3 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Maciej Dlugosz and Joanna Trylska review recent developments in particle-based Brownian dynamics algorithms and their application to model diffusive transport in crowded systems, which are proving useful in improving our understanding of metabolism, transport and signaling.
	12. 141 Accesses	Review Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations Balaji VS Iyer, Martin Kenward, Gaurav Arya BMC Biophysics 2011, 4:8 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gaurav Arya and colleagues review results from state-of-the-art microscopy and chromosome conformation capture techniques that are being used to understand the three dimensional structure of the genome and the physical principles governing its folding.
	13. 126 Accesses	Research article Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms Daniel Neumann, Johanna Bückers, Lars Kastrup, Stefan W Hell, Stefan Jakobs PMC Biophysics 2010, 3:4 (5 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The voltage-dependent anion channel (VDAC, also known as mitochondrial porin) is the major transport channel mediating the transport of metabolites, including ATP, across the mitochondrial outer membrane. In this study we show that whereas hVDAC1 and hVDAC2 are localized predominantly within the same distinct domains in the outer membrane, hVDAC3 is mostly uniformly distributed over the surface of the mitochondrion.
	14. 124 Accesses	Research article Many-particle Brownian and Langevin Dynamics Simulations with the Brownmove package Tihamér Geyer BMC Biophysics 2011, 4:7 (13 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new "brownmove" simulation package designed for coarse-grained many-particle simulations of biologically relevant diffusion and transport processes combines Brownian and Langevin Dynamics propagation with fast hydrodynamics, a flexible protein model and interfaces for "open" simulation settings.
	15. 121 Accesses	Research article The influence of membrane physical properties on microvesicle release in human erythrocytes Laurie J Gonzalez, Elizabeth Gibbons, Rachel W Bailey, Jeremy Fairbourn, Thaothanh Nguyen, Samantha K Smith, Katrina B Best, Jennifer Nelson, Allan M Judd, John D Bell PMC Biophysics 2009, 2:7 (24 August 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Exposure of human erythrocytes to elevated intracellular calcium causes fragments of the cell membrane to be shed as microvesicles. This study tested the hypothesis that microvesicle release depends on microscopic membrane physical properties such as lipid order, fluidity, and composition.
	16. 118 Accesses	Research article On the electrostatic component of protein-protein binding free energy Kemper Talley, Carmen Ng, Michael Shoppell, Petras Kundrotas, Emil Alexov PMC Biophysics 2008, 1:2 (5 November 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper presents a comprehensive statistical analysis of the sensitivity of the electrostatic component of binding free energy (DDGel) with respect with different force fields (Charmm, Amber, and OPLS), different values of the internal dielectric constant, and different presentations of molecular surface (different values of the probe radius).
	17. 113 Accesses	Research article Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data Mizuki Morita, AVSK Katta, Shandar Ahmad, Takaharu Mori, Yuji Sugita, Kenji Mizuguchi BMC Biophysics 2011, 4:21 (14 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tightly-bound lipid molecules and lipids in the annular shell interact with membrane proteins in a similar manner, largely explained by general lipophilicity, that suggests a common pattern of lipid tail-amino acid interactions
	18. 107 Accesses	Research article Stability of double-stranded oligonucleotide DNA with a bulged loop: a microarray study Christian Trapp, Marc Schenkelberger, Albrecht Ott BMC Biophysics 2011, 4:20 (13 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Stable DNA duplexes with a bulged loop can form from short strands of unequal length with duplex stability decreasing monotonically with the length of the bulged loop, contributing substantially to microarray fluorescence intensity
	19. 105 Accesses	Research article ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations Muhammad S Ahmad, Bushra Mirza, Mukhtiar Hussain, Muhammad Hanif, Saqib Ali, Michael J Walsh, Francis L Martin PMC Biophysics 2008, 1:3 (5 November 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. This work shows that IR spectra, derived following ATR-FTIR spectroscopy, from organotin-treated MCF-7 cells exhibit molecular alterations following low-dose exposures. This approach highlights the potential applicability of mid-IR spectroscopy to signature toxic effects at sub-lethal concentrations following typical environmental exposures to environmental contaminants.
	20. 108 Accesses	Review Gated Diffusion-controlled Reactions J Andrew McCammon BMC Biophysics 2011, 4:4 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Andy McCammon discusses both the protein-centric and detailed dynamic simulation methods that have been applied to predict rates of ligand binding and reactivity at protein active sites and the biological implications of these findings.
	21. 105 Accesses	Research article An upper limit for macromolecular crowding effects Andrew C Miklos, Conggang Li, Courtney D Sorrell, L Andrew Lyon, Gary J Pielak BMC Biophysics 2011, 4:13 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Synthetic microgels that interact weakly with proteins do not strongly influence protein dynamics or stability because these large microgels constitute an upper size limit on crowding effects.
	22. 105 Accesses	Research article Spindles and active vortices in a model of confined filament-motor mixtures David A Head, WJ Briels, Gerhard Gompper BMC Biophysics 2011, 4:18 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A discrete filament-motor protein model of subcellular microtubule self-assembly in fission yeast spontaneously generates a number of steady states, including spindles, nematics, and asters, highlighting potential mechanisms for self-organisation in filaments
	23. 102 Accesses	Research article Sensing the Heat Stress by Mammalian Cells Jordan Cates, Garrett C Graham, Natalie Omattage, Elizabeth Pavesich, Ian Setliff, Jack Shaw, Caitlin Smith, Ovidiu Lipan BMC Biophysics 2011, 4:16 (11 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new system-level mathematical approach is proposed to model the heat-shock response network in mammalian cells and the key heat-shock transcription factor-1 (HSF) which is transiently activated by elevated temperatures.
	24. 96 Accesses	Research article Kinetics of diffusion-controlled enzymatic reactions with charged substrates Benzhuo Lu, J Andrew McCammon PMC Biophysics 2010, 3:1 (18 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We show in this work that through numerical solution of the Poisson-Nernst-Planck equations, diffusion-reaction processes can be studied at a variety of conditions including realistically concentrated solutions, high ionic strength, and certainly with non-equilibrium charge distributions.
	25. 91 Accesses	Research article Diffusion of hydrophobin proteins in solution and interactions with a graphite surface Paolo Mereghetti, Rebecca C Wade BMC Biophysics 2011, 4:9 (21 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hydrophobins, the most powerful surface-active proteins known, exist in solution as a mixture of monomers in equilibrium with different types of oligomers but in contact with a graphite layer they form tetramers and accumulate close to the hydrophobic surface.