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Volume 2 (2009) - May 2009

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Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruzi ribosomal P proteins and their interaction with a monoclonal antibody structural model

Osvaldo A Martín, Myriam E Villegas, Carlos F Aguilar PMC Biophysics 2009, 2:4 (27 May 2009)

Abstract | Full text | PDF | PubMed | Editor’s summary

This work describes clearly the interactions of the structural elements involved in the autoimmune mechanism of anti-P auto-antibodies cross-reaction and stimulation of the beta1-adrenoreceptor and the visual pigment rhodopsin in the heart. Results from this study could lead eventually to the development of treatments to abolish receptor mediated symptoms in Chagas' disease.