- Sabato D'Auria, CNR
- Chris Grant, University of Manchester
- John Honek, University of Waterloo
- Albert Jeltsch, Universität Stuttgart
- Tom Rowles, BioMed Central
A proteoliposome fusion assay provides evidence for functional overlap between members of the SYP4 and VTI1 groups of Arabidopsis thaliana SNARE proteins in membrane fusion, in support of previously published genetic data.
Mutating Arg48, Trp51, and His52 in the distal heme pocket of cytochrome C peroxidase to alanines improves the binding affinity of apolar substrates and escalates turnover rate, though the constructs are more susceptible to oxidative degradation.
BMC Biochemistry 2011, 12:58
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Section Editor's profile
John F. Honek is currently Professor and Chair of the Department of Chemistry at the University of Waterloo, Ontario, Canada.
Dr. Honek’s laboratory focuses on the structure and function of enzymes involved in methionine biochemistry, the Glyoxalase metalloenzymes and several protein targets of potential importance in medicinal chemistry. Recently Dr. Honek’s group has extended their investigations to the application of multisubunit protein systems to bionanomaterial fabrication.
"BMC Biochemistry is an important publication outlet for useful biochemistry research. The journal was created to provide an open access forum for leading edge investigations and provides freely available literature to the scientific community. This open forum provides anyone, regardless of their professional associations or financial capabilities, immediate access to world-class research investigations in biochemistry. We believe this accessible knowledge will stimulate many new ideas for future biochemical research among scientists throughout the world."