Table 4

Parametric estimates and confidence intervals (α = 0.05) from the equation (1) applied to the aggregation of Aβ42-amyloid protein increased data influenced by apigenin, ectoine, hidroxyectoine and taiwaniaflavone concentrations
Parameters Apigenin Ectoine Hidroxyectoine Taiwaniaflavone Trehalose
Aggregation model Xm (AU) 17.43±0.50 (5.07±0.23) × 10−3 (4.96±0.24) × 10−3 16.55±0.55 10.49±0.28
vm (AU h−1 or AU d−1) 16.10±1.49 (0.24±0.05) × 10−3 (0.30±0.08) × 10−3 17.01±2.09 3.31±0.33
λ (h or d) 0.25±0.03 11.60±2.26 13.50±2.31 0.27±0.06 5.76±0.14
Effect on Xm Kx 0.41±0.06 1.00±0.99 1.00±0.90 0.78±0.05 0.44±0.03
mx (mM or μM) 6.52±1.93 11.82±11.03 66.70±65.78 2.32±0.38 51.58±7.27
ax 0.91±0.25 0.19±0.13 0.43±0.43 0.98±0.16 1.36±0.31
Effect on vm Kv 0.38±0.12 0.83±0.06 0.86±0.16 1.14±0.60 0.53±0.08
mv (mM or μM) 9.29±5.35 0.33±0.32 1.35 (NS) 1.88±1.73 33.22±17.26
av 1.35±1.13 0.36±0.14 0.34±0.20 0.40±0.21 0.66±0.33
Effect on λ Kλ 1.76±0.70 NS NS 1.27±1.13 NS
mλ (mM or μM) 2.16±0.29 NS NS 2.53±1.45 NS
aλ 2.39±0.99 NS NS 2.33±2.31 NS
EC50,τ (mM or μM) 2.45 0.96 2.20 0.91 21.43
τ (h or d) 0.75 17.31 20.52 0.65 6.54
p-value <0.001 <0.001 <0.001 <0.001 <0.001
Bf 0.99 1.04 1.00 1.02 1.03
Af 1.06 1.09 1.18 1.11 1.08
R2adj 0.995 0.988 0.984 0.990 0.995

The case of apomyoglobin affected by trehalose is also shown. Statistical values of adjusted coefficient of multiple determination (R2adj) and p-values from Fisher’s F-test (α = 0.05). Bf and Af are the bias and accuracy factor, respectively. NS: non-significant.

Vázquez

Vázquez BMC Pharmacology and Toxicology 2014 15:9   doi:10.1186/2050-6511-15-9

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