Table 4

Multivariate analysis of the baseline factors associated with changes in antihypertensive drug treatment, CoLaus study
Combiners Switchers Discontinuers
Women vs. men 0.79 (0.55 - 1.12) 0.94 (0.60 - 1.48) 0.42 (0.21 - 0.81)
ARB (yes vs. no) 0.77 (0.53 - 1.13) 0.31 (0.18 - 0.52) 0.48 (0.23 - 0.98)
Hypertension (yes vs. no) 1.69 (1.18 - 2.42) 1.09 (0.69 - 1.72) 0.66 (0.35 - 1.23)
Treatment regimen
 Several pills 1 (ref) 1 (ref) 1 (ref)
 One pill, combination 1.06 (0.63 - 1.79) 1.78 (0.94 - 3.38) 1.48 (0.49 - 4.47)
 One pill, single drug 3.21 (2.06 - 5.00) 1.55 (0.88 - 2.74) 4.06 (1.68 - 9.83)
BMI status
 Normal 1 (ref) 1 (ref) 1 (ref)
 Overweight 1.83 (1.13 - 2.95) 0.95 (0.55 - 1.66) 1.52 (0.71 - 3.24)
 Obese 2.35 (1.42 - 3.88) 0.96 (0.53 - 1.76) 0.76 (0.29 - 1.98)

ARB, angiotensin receptor blocker; BMI, body mass index. Statistical analysis by multinomial (polytomous) logistic regression, using continuers as the reference group. Hypertension was defined as a systolic blood pressure ≥140 mm Hg or a diastolic blood pressure ≥90 mm Hg. Results are expressed as relative risk ratio and (95% confidence interval).

Christe et al.

Christe et al. BMC Pharmacology and Toxicology 2014 15:20   doi:10.1186/2050-6511-15-20

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