Maximal endothelial NO and ONOO- concentrations, and [NO]/[ONOO-] ratio stimulated with nebivolol and ATP following a PEG-SOD and VAS2870 incubation. (A) Maximal NO and ONOO- concentrations stimulated with nebivolol and ATP (each at 1 μM) following a 30-minute incubation of HUVECs with PEG-SOD (400 U/mL) and VAS2870 (5 μM). Values are mean ± SD (n = 5). Student’s t-test: *P < 0.05 compared with nebivolol. (B) The [NO]/[ONOO-] ratio calculated from the maximal concentration in A. Values are mean ± SD (n = 5). Student’s t-test: *P < 0.05 compared with [NO]/[ONOO-] balance calculated for nebivolol.
Mason et al. BMC Pharmacology and Toxicology 2013 14:48 doi:10.1186/2050-6511-14-48