Representative amperograms showing endothelial NO and ONOO- release stimulated with nebivolol, L-755,507, 2-MeSATP, and ATP. NO (A) and ONOO-(B) release from HUVECs were stimulated with nebivolol, ATP, 2-MeSATP, or L-755,507 (each at 1 μM). The amperograms of the 2-MeSATP partially overlaps that of L-755,507 and are omitted. NO and ONOO- release were measured with electrochemical nanosensors positioned 5 ± 2 μm from the surface of a single cell. Arrows indicate compound administration.
Mason et al. BMC Pharmacology and Toxicology 2013 14:48 doi:10.1186/2050-6511-14-48