Email updates

Keep up to date with the latest news and content from BMC Pharmacology and Toxicology and BioMed Central.

This article is part of the supplement: 18th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Open Access Meeting abstract

The galanin system in depression and antidepressant treatment: focus on the locus coeruleus

Simone B Sartori1*, Anupam Sah1, Baosheng Zhao1, Inga Neumann2, Rainer Landgraf3 and Nicolas Singewald1

Author Affiliations

1 Department of Pharmacology and Toxicology, University of Innsbruck, 6020 Innsbruck, Austria

2 Department of Zoology, University of Regensburg, 93040 Regensburg, Germany

3 Max-Planck Institute of Psychiatry, 80804 Munich, Germany

For all author emails, please log on.

BMC Pharmacology and Toxicology 2012, 13(Suppl 1):A75  doi:10.1186/2050-6511-13-S1-A75

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/2050-6511/13/S1/A75


Published:17 September 2012

© 2012 Sartori et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Our knowledge about central changes underlying depressive disorders is still incomplete, but disturbances in monoaminergic neurotransmission are involved. There is also increasing evidence for a possible role of the neuropeptide galanin and its three G protein-coupled receptors in the pathophysiology and treatment of depression [1].

Methods

Using in situ hybridization we investigated whether transcriptional processes in the galanin system may be involved in the heightened depression-like behaviour of HAB rats selectively bred for high trait anxiety as compared with their low anxiety/depression (LAB) counterparts [2] and in the treatment responses to established antidepressant drugs. Subsequently, the modulation of depression-related behaviour by intra-cerebrally applied galaninergic ligands was studied in HAB and LAB rats.

Results

The abundance of galanin mRNA was increased in the paraventricular hypothalamus, the central amygdala and the locus coeruleus (LC), but not in the dorsal raphe of HAB as compared to LAB animals. Conversely, long-term (42 days, p.o.) treatment with either desipramine, paroxetine or tranylcypromine caused a general reduction in galanin mRNA expression in the locus coeruleus (LC) of unselected rats indicating a common response to antidepressant drug treatment while in the paraventricular hypothalamus galanin mRNA was increased by tranylcypromine only. This observed common effect of the antidepressants on galanin mRNA in the LC is in contrast to the finding in the HAB model raising the exciting possibility that altered coerulear galanin mRNA expression may be associated with depression-related behaviour. Indeed, intra-LC galanin caused a pronounced increase in the immobility of LAB rats indicating enhanced depression-like behaviour while a galanin receptor antagonist reduced immobility in HAB rats.

Conclusions

The present data suggest that depression-like behaviours can be altered by interference with the galanin system and, thus, the galanin system may represent an interesting target for novel antidepressant pharmacotherapy. In particular, its modulation in the LC, where galanin highly coexists with noradrenaline, appears to be critical.

Acknowledgements

Supported by the Austrian Science Fund FWF and a Young Investigator Funding of the University of Innsbruck.

References

  1. Kuteeva E, Hökfelt T, Wardi T, Ogren SO: Galanin, galanin receptor subtypes and depression-like behaviour.

    EXS 2010, 16:3071-3088. PubMed Abstract OpenURL

  2. Landgraf R, Wigger A: High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety.

    Behav Genet 2002, 32:301-314. PubMed Abstract | Publisher Full Text OpenURL