Table 1

Permeation parameters
Substance
Diclofenac Ibuprofen Ketoprofen Paracetamol
Parameter Control 200 μm 300 μm Control 200 μm 300 μm Control 200 μm 300 μm Control 200 μm 300 μm
Jmax (μg/cm²/h) 1.72 8.75 11.55 167.78 368.69 431.52 1.03 2.36 2.99 2.58 9.97 19.42
10-6 Papp (cm/s) 0.18 0.93 1.24* 1.92 4.21 5.27* 0.12 0.28 0.35* 0.04 0.16 0.31*
Recovery (%) 0.49 3.17 3.54 6.76 11.15 17.75 0.30 0.76 0.96 0.14 0.55 1.06

Mean permeation parameters following substance application to bovine skin; * = p<0.05 (microneedle versus control), n = 5–6.

Stahl et al.

Stahl et al. BMC Pharmacology and Toxicology 2012 13:5   doi:10.1186/2050-6511-13-5

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