Figure 2.

Molecular mechanism for agonist-directed biased signaling. Agonist A stabilizes a conformation of the receptor that preferably activates pathway 1 while agonist B stabilizes a receptor conformation that preferably activates pathway 2.

Kenakin BMC Pharmacology and Toxicology 2012 13:3   doi:10.1186/2050-6511-13-3
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