Different adhesion and protrusion characteristics correlate with EGF stimulation and cell speed. Cells can either be grouped based on EGF concentration or cell speed. EGF concentration is considered an input that acts to regulate adhesion and protrusion characteristics, whereas cell speed is an output that acts to integrate information determined by inputs such as EGF concentration. Both FA intensity and number per cell correlate with EGF concentration, whereas FA intensity and the presence or absence of protrusion waves correlate with cell speed. Cell speed could be regulated by EGF through changes in FA intensity, but other inputs are most likely needed to regulate the presence of protrusion waves, since EGF concentration correlates poorly with the presence or absence of protrusion waves.
Hou et al. BMC Biophysics 2012 5:8 doi:10.1186/2046-1682-5-8