Spatial asymmetry in [R ∼ P] is not sensitive to branching.A) Schematic of a branched cell with oppositely localized kinase and phosphatase in the rod-shaped region of the cell. The branch occurs at midcell at a right angle to the rest of the cell, and has length Lb. B) 3D mathematical modeling of the distribution of [R ∼ P] in a branched cell with Lb = 0.5 μm. C) [R ∼ P] line scan through the cell middle showing volume-weighted average density along cell length (along the dashed line in A) for varying branch lengths. D) Schematic of 1D distribution of kinase and phosphatase activities that produce profiles mimicking those in (C) for Lb > 0.5 μm, with background kinase and phosphatase localized at the middle of the cell and overlapping by L/10.
Tropini et al. BMC Biophysics 2012 5:17 doi:10.1186/2046-1682-5-17