Localized degradation does not significantly affect to the R ∼ P gradient even at high proteolysis rates.A) Schematic of the localization of source and sink. Synthesis occurs throughout the cell, whereas degradation occurs only at the phosphatase pole. B) Mathematical modeling of the effects of proteolysis on the distributions of R ∼ P for α = 1/τD. (Left inset) The total amount of substrate is not uniform. (Right inset) The ratio of R ∼ P between the two poles is independent of the synthesis rate.
Tropini et al. BMC Biophysics 2012 5:17 doi:10.1186/2046-1682-5-17