Table 7

Persistent edges categorized based on the long-range contacts between different domains
Edge category Subset containing RT residues
EC – TM [7]* EC – RT[7]:
A2726.55 - S176EC2, A2726.55 - Y178EC2, A2927.39 - Y29EC (N-terminus), S186EC2 - P2917.38, E1223.37 - E196EC3, G1143.29 - S176EC2, G1143.29 - Y178EC2
TM – TM [17] TM(not RT) – TM(not RT) [1]:
G902.57 - G1203.35
RT – TM [10]:
A1173.32 - G902.57, E1133.28 - M441.39, E1133.28 - W1263.41, H2115.46 - F912.58, E1223.37 - I481.43, E1223.37 - G902.57, E1223.37 - M2075.42, G902.57 - M2075.42, G902.57 - A2696.52, G902.57 - F2937.40
RT – RT [6]:
A1173.32 - F2937.40, A1173.32 - K2967.43, A2726.55 - G1143.29, E1133.28 - F2937.40, E1223.37 - A2696.52, E1223.37 - F2937.40
TM – IC [8] TM(not RT) – IC [1]:
G902.57 - Q237IC3
RT – IC [7]:
A1173.32 - E247 IC3, A2726.55 - L72IC1, E1133.28 - L72IC1, H2115.46 - C140 IC2, H2115.46 - F148 IC2, E1223.37 - C316IC (C-terminus), M2075.42 - C316IC (C-terminus)
EC – IC [2] RT – IC [2]:
S186EC2 - K67IC1, S186EC2 - Q244IC3

*The number of edges in category is given in brackets.

Categorization of edges based on the long-range contacts between the EC, IC and TM domains. The number of edges are in each category are given in brackets. There are a total of 34 edges formed by top 10 ranking residues at penalty λ = 140. There are no edges in the EC – EC and IC – IC categories. In the second column, the edges are sub-categorized to include the RT domain. Ballesteros-Weinstein numbering (superscript) is given for comparison with other GPCRs. Only long-range edges are reported. These are edges where neighbouring residues (8 amino acids on either side) are filtered out. *The number of total edges is given in brackets.

Moitra et al.

Moitra et al. BMC Biophysics 2012 5:13   doi:10.1186/2046-1682-5-13

Open Data