Table 2

Thermodynamic parameters of the protonation of inhibitor sulfonamide group and hCA XIII zinc-bound hydroxide anion at 25°C
Δb_protonH, kJ/mol pKa Ka, M Δb_protonG, kJ/mol TΔb_protonS, kJ/mol Δb_protonS, J/(mol × K) Δb_protonCp, J/(mol × K)
EZA −29.5 8.0 1.0 × 10-8 −45.7 16.2 54.2 88.7
TFMSA −23.9 6.25 5.6 × 10-7 −35.7 11.8 39.5 124.7
AZMa −23.0 7.30 5.0 × 10-8 −41.7 18.7 62.6 ND
CA-Zn-H2O −26.0 8.25 5.6 × 10-9 −47.1 21.1 70.7 ND

Standard deviations are below 10% for all parameters measured in kJ/mol.

a – data taken from [30].

Baranauskienė and Matulis

Baranauskienė and Matulis BMC Biophysics 2012 5:12   doi:10.1186/2046-1682-5-12

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