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Open Access Open Badges Case Report

An unusual unifocal presentation of Castleman’s disease in a young woman with a detailed description of sonographic findings to reduce diagnostic uncertainty: a case report

Norbert Wagner1* and Zerrin Maden2

Author Affiliations

1 Department of Obstetrics and Gynecology, Marienhospital Essen, Hospitalstrasse 24, Essen 45329, Germany

2 Department of Obstetrics and Gynecology, University Hospital Frankfurt, Theodor Stern Kai 7, Frankfurt 60590, Germany

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BMC Research Notes 2013, 6:97  doi:10.1186/1756-0500-6-97

Published: 15 March 2013



Castleman’s disease is a rare lymphoproliferative disorder. It typically presents as mediastinal masses and causes a wide range of clinical symptoms. Histologically, Castleman’s disease is classified as either a hyalinic vascular or plasma cell variant. The prognosis mainly depends on the histological type and broadly varies. We herein report our sonographic findings in a patient with Castleman’s disease, including gray-scale ultrasonography, color Doppler ultrasonography, and sonoelastography ultrasonography, which have not been previously reported in the literature. These findings allowed for a preoperative diagnosis and avoidance of overly aggressive therapy.

Case presentation

A 28-year-old European female patient with unicentric Castleman’s disease of hyalinic vascular type (HV) restricted to the axilla was referred to us because of a 4-month history of a painless, solitary mass located in the left axilla. The patient’s medical history was unremarkable.


Castleman’s disease is a pathologic entity of unknown etiology and pathogenesis. In this case report of unicentric HV-type CD, we demonstrate that typical sonographic findings can lead to a preoperative diagnosis of Castleman’s disease. Core needle biopsy usually allows for a final diagnosis and helps to avoid unnecessary operations and overtreatment.

Castleman’s disease; Giant lymph node hyperplasia; Ultrasonography; Core needle biopsy