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Open Access Case Report

A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report

Fabio Bonilla-Abadía1*, Evelyn Muñoz-Buitrón23, Carlos D Ochoa1, Edwin Carrascal4 and Carlos A Cañas1

Author Affiliations

1 Rheumatology Unit. Fundación Valle del Lili, ICESI University, Avenida Simón Bolívar Cra.98, No.18-49, Cali, Colombia

2 University of Medical Sciences, La Habana, Cuba

3 Fundación Valle del Lili, Cali, Colombia

4 Pathology Unit. Fundación Valle del Lili, and Faculty of Health Sciences, Universidad del Valle, Cali, Colombia

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BMC Research Notes 2012, 5:689  doi:10.1186/1756-0500-5-689

Published: 20 December 2012

Abstract

Background

The localized scleroderma (LS) known as morphea, presents a variety of clinical manifestations that can include systemic involvement. Current classification schemes divide morphea into categories based solely on cutaneous morphology, without reference to systemic disease or autoimmune phenomena. This classification is likely incomplete. Autoimmune phenomena such as vitiligo and Hashimoto thyroiditis associated with LS have been reported in some cases suggesting an autoimmune basis. To our knowledge this is the first case of a morphea forming part of a multiple autoimmune syndrome (MAS) and presenting simultaneously with autoimmune thrombocytopenic purpura and central nervous system vasculitis.

Case presentation

We report an uncommon case of a white 53 year old female patient with LS as part of a multiple autoimmune syndrome associated with pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis presenting a favorable response with thrombopoietin receptor agonists, pulses of methylprednisolone and cyclophosphamide.

Conclusion

Is likely that LS have an autoimmune origin and in this case becomes part of MAS, which consist on the presence of three or more well-defined autoimmune diseases in a single patient.

Keywords:
Localized scleroderma; Morphea; Multiple autoimmune syndrome; Central nervous system vasculitis