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Open Access Short Report

Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients

Daniela Tenório Furgeri1, Fernando Augusto de Lima Marson2, Antonio Fernando Ribeiro2 and Carmen Silvia Bertuzzo13*

Author Affiliations

1 Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil

2 Department of Pediatrics, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil

3 Universidade Estadual de Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126, Cidade Universitária, Campinas, SP 13081-970, Brazil

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BMC Research Notes 2012, 5:561  doi:10.1186/1756-0500-5-561

Published: 10 October 2012

Abstract

Background

Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF.

Findings

We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients.

Conclusions

In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.

Keywords:
rs12255372; IVS4G > T; TCF7L2; Cystic fibrosis; Diabetes