Table 3

Association of genes SNPs with opiate drug dependence
Gene SNP _ID SNP M_Aa F_Ab F_Uc Pearson chi-square p-valued OR CMHe
DRD1 rs5326 G > A A 0.172 0.144 1.32 0.256 0.256
DRD2 rs1800496 C > T T 0.027 0.015 1.86 0.173 1.903
rs6277 T > C T 0.427 0.460 1.05 0.307 0.873
rs2511521 T > C G 0.370 0.383 0.16 0.685 0.946
rs12574471 C > T T 0.196 0.161 1.85 0.173 1.265
rs2283265 G > T T 0.146 0.087 8.70 0.001 2.785
rs6279 C > G C 0.406 0.435 0.79 0.374 0.888
rs4581480 T > C C 0.095 0.075 1.29 0.256 1.308
rs4350392 C > A A 0.173 0.217 2.82 0.093 0.755
rs10891556 G > T T 0.187 0.235 3.18 0.074 0.748
rs7103679 C > T T 0.121 0.083 3.48 0.062 1.506
rs4938019 T > C C 0.170 0.216 3.13 0.076 0.743
rs1076560 G > T T 0.157 0.108 4.73 0.031 1.531
rs2075654 G > A A 0.120 0.075 5.43 0.021 1.689
rs7125415 C > T T 0.100 0.118 0.78 0.376 0.829
rs4648317 C > T T 0.170 0.216 3.12 0.076 0.743
rs1125394 A > G G 0.152 0.091 8.00 0.001 1.780
rs4648318 A > G G 0.379 0.361 0.29 0.593 1.080
rs12363125 A > G C 0.513 0.472 1.52 0.217 1.170
rs2734836 G > A A 0.146 0.090 7.00 0.001 1.720
rs12364283 T > C G 0.097 0.129 2.24 0.134 0.730
rs1799978 A > G G 0.141 0.110 2.03 0.154 1.330
rs6275 C > T T 0.404 0.429 0.60 0.440 0.900
rs1800497 C > T T 0.195 0.156 2.37 0.123 1.310
rs1799732 -C -C 0.146 0.067 21.00 0.260E-4 3.370
rs1800498 C > T C 0.509 0.466 1.66 0.190 1.180
DRD3 rs6280 C > T C 0.355 0.370 0.21 0.645 0.938
DRD4 rs3758653 C > T C 0.263 0.287 0.66 0.410 0.886
DRD5 rs10033951 C > T T 0.306 0.325 0.36 0.550 0.917
SLC6A3 rs2963238 A > C A 0.436 0.462 0.63 0.427 0.899
rs6876225 C > A A 0.027 0.035 0.49 0.480 0.764
rs11564773 A > G G 0.043 0.437 0.00 0.978 0.991
rs1042098 T > C C 0.363 0.342 0.42 0.515 1.094
BDNF1 rs7103873 C > G C 0.463 0.510 2.02 0.154 0.827
rs1401635 C > G C 0.231 0.212 0.50 0.481 1.118
rs11030102 C > G G 0.163 0.138 1.17 0.279 1.221
rs17309930 A > C,G > T A 0.136 0.127 0.17 0.679 1.084
rs6265 G > A A 0.182 0.161 0.748 0.387 1.164
COMT rs737866 T > C C 0.363 0.312 2.69 0.100 1.259
rs4680 A > G A 0.475 0.502 0.67 0.411 0.897

a.M_A: minor allele for whole cohort sample.

b.F_A: minor allele frequency in affected individuals (substance addiction cases).

c.F_U: minor allele frequency in unaffected individuals (healthy controls).

d.p-value: two tailed p-value from the 2x2 allele count chi-squared test; p <0.05 (Bonferroni-adjusted).

e.OR CMH: allelic odds ratio from the 2x2xK Cochran-Mantel-Haenszel’s test.

AL-Eitan et al.

AL-Eitan et al. BMC Research Notes 2012 5:497   doi:10.1186/1756-0500-5-497

Open Data