Photomicrographs of colonic tissue immunohistochemically stained for PSCA. Intense staining can be seen in a crypt neuroendocrine cell (1A, arrow). Colonocytes show little or no staining across all stages of the adenoma-carcinoma sequence. No changes in intensity or topographic distribution of PSCA expression were observed between normal mucosa (1B), adenomatous tissue displaying low grade epithelial dysplasia (1C), and invasive carcinoma (1D).
Smith et al. BMC Research Notes 2012 5:371 doi:10.1186/1756-0500-5-371