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Open Access Highly Accessed Research article

Clinical and laboratory characteristics of infectious mononucleosis by Epstein-Barr virus in Mexican children

Napoleón González Saldaña1, Victor Antonio Monroy Colín1, Georgina Piña Ruiz1 and Hugo Juárez Olguín23*

Author Affiliations

1 Department of Infectious Diseases, National Institute of Pediatrics, Avenida Insurgentes Sur 3700-C, Mexico City, 04530, Mexico

2 Laboratory of Pharmacology, National Institute of Pediatrics (Avenida Imán N° 1), 3rd piso Colonia Cuicuilco, CP 04530, Mexico City, Mexico

3 Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, 04510, Mexico

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BMC Research Notes 2012, 5:361  doi:10.1186/1756-0500-5-361

Published: 20 July 2012

Abstract

Background

Infectious mononucleosis (IM) or Mononucleosis syndrome is caused by an acute infection of Epstein-Barr virus. In Latin American countries, there are little information pertaining to the clinical manifestations and complications of this disease. For this reason, the purpose of this work was to describe the clinical and laboratory characteristics of infection by Epstein-Barr virus in Mexican children with infectious mononucleosis.

Methods

A descriptive study was carried out by reviewing the clinical files of patients less than 18 years old with clinical and serological diagnosis of IM by Epstein-Barr virus from November, 1970 to July, 2011 in a third level pediatric hospital in Mexico City.

Results

One hundred and sixty three cases of IM were found. The most frequent clinical signs were lymphadenopathy (89.5%), fever (79.7%), general body pain (69.3%), pharyngitis (55.2%), hepatomegaly (47.2%). The laboratory findings were lymphocytosis (41.7%), atypic lymphocytes (24.5%), and increased transaminases (30.9%), there were no rupture of the spleen and no deaths among the 163 cases.

Conclusions

Our results revealed that IM appeared in earlier ages compared with that reported in industrialized countries, where adolescents are the most affected group. Also, the order and frequency of the clinical manifestations were different in our country than in industrialized ones.

Keywords:
Epstein-Barr virus; Mononucleosis; Pediatric infections