Email updates

Keep up to date with the latest news and content from BMC Research Notes and BioMed Central.

Open Access Short Report

Clinical characteristics of pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Northern Bavaria, Germany

Anna Wieching1, Jasmin Benser1, Christina Kohlhauser-Vollmuth2, Benedikt Weissbrich3, Andrea Streng1 and Johannes G Liese1*

Author affiliations

1 University Children’s Hospital, Pediatric Infectiology and Immunology, Julius-Maximilians-University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany

2 Department of Pediatrics, Missio Hospital Wuerzburg, Salvatorstr. 7, 97067, Wuerzburg, Germany

3 Institute for Virology and Immunobiology, Julius-Maximilians-University of Wuerzburg, Versbacherstr. 7, 97078, Wuerzburg, Germany

For all author emails, please log on.

Citation and License

BMC Research Notes 2012, 5:304  doi:10.1186/1756-0500-5-304

Published: 18 June 2012

Abstract

Background

The 2009 pandemic influenza A (H1N1) (PIA) virus infected large parts of the pediatric population with a wide clinical spectrum and an initially unknown complication rate. The aims of our study were to define clinical characteristics and outcome of pandemic influenza A (H1N1) 2009-associated hospitalizations (PIAH) in children <18 years of age. All hospitalized cases of children <18 years of age with laboratory-confirmed pandemic influenza A (H1N1) 2009 in the region of Wuerzburg (Northern Bavaria, Germany) between July 2009 and March 2010 were identified. For these children a medical chart review was performed to determine their clinical characteristics and complications.

Results

Between July 2009 and March 2010, 94 PIAH (62% males) occurred in children <18 years of age, with a median age of 7 years (IQR: 3–12 years). Underlying diseases and predisposing factors were documented in 40 (43%) children; obesity (n = 12, 30%), asthma (n = 10, 25%) and neurologic disorders (n = 8, 20%) were most frequently reported. Sixteen (17%) children received oxygen supplementation; three (3%) children required mechanical ventilation. Six (6%) children were admitted to an intensive care unit, four of them with underlying chronic diseases.

Conclusions

Most PIAH demonstrated a benign course of disease. However, six children (6%) needed treatment at an intensive care unit for severe complications.

Keywords:
Influenza; Pediatric; Infectious disease; Hospitalization