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Clinical characteristics of pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Northern Bavaria, Germany

Anna Wieching1, Jasmin Benser1, Christina Kohlhauser-Vollmuth2, Benedikt Weissbrich3, Andrea Streng1 and Johannes G Liese1*

Author affiliations

1 University Children’s Hospital, Pediatric Infectiology and Immunology, Julius-Maximilians-University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany

2 Department of Pediatrics, Missio Hospital Wuerzburg, Salvatorstr. 7, 97067, Wuerzburg, Germany

3 Institute for Virology and Immunobiology, Julius-Maximilians-University of Wuerzburg, Versbacherstr. 7, 97078, Wuerzburg, Germany

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Citation and License

BMC Research Notes 2012, 5:304  doi:10.1186/1756-0500-5-304

Published: 18 June 2012



The 2009 pandemic influenza A (H1N1) (PIA) virus infected large parts of the pediatric population with a wide clinical spectrum and an initially unknown complication rate. The aims of our study were to define clinical characteristics and outcome of pandemic influenza A (H1N1) 2009-associated hospitalizations (PIAH) in children <18 years of age. All hospitalized cases of children <18 years of age with laboratory-confirmed pandemic influenza A (H1N1) 2009 in the region of Wuerzburg (Northern Bavaria, Germany) between July 2009 and March 2010 were identified. For these children a medical chart review was performed to determine their clinical characteristics and complications.


Between July 2009 and March 2010, 94 PIAH (62% males) occurred in children <18 years of age, with a median age of 7 years (IQR: 3–12 years). Underlying diseases and predisposing factors were documented in 40 (43%) children; obesity (n = 12, 30%), asthma (n = 10, 25%) and neurologic disorders (n = 8, 20%) were most frequently reported. Sixteen (17%) children received oxygen supplementation; three (3%) children required mechanical ventilation. Six (6%) children were admitted to an intensive care unit, four of them with underlying chronic diseases.


Most PIAH demonstrated a benign course of disease. However, six children (6%) needed treatment at an intensive care unit for severe complications.

Influenza; Pediatric; Infectious disease; Hospitalization