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Open Access Short Report

Etiologic profile and antimicrobial susceptibility of community-acquired urinary tract infection in two Cameroonian towns

Jane-Francis Tatah Kihla Akoachere12*, Suylika Yvonne1, Njom Henry Akum2 and Esemu Nkie Seraphine2

Author Affiliations

1 Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon

2 Laboratory for Emerging Infectious Diseases, Faculty of Science, University of Buea, Buea, Cameroon

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BMC Research Notes 2012, 5:219  doi:10.1186/1756-0500-5-219

Published: 7 May 2012

Abstract

Background

Urinary tract infection (UTI) represents one of the most common diseases encountered in community medical practice. In resource poor settings, treatment is usually empiric due to the high cost and long duration required for reporting diagnosis by culture and antibiotic susceptibility testing. With the growing problem of drug resistance knowledge of antibiotic susceptibility pattern is pertinent for successful eradication of invading pathogens. Our study, the first of its kind in Cameroon, analyzed the distribution and antibiotic susceptibility of bacteria causing community-acquired urinary tract infection (CAUTI) in two towns (Bamenda and Buea) with a large number of young and middle aged persons, to provide data that could guide empiric treatment.

Findings

We cultured 235 urine specimens and analyzed the antibiotic susceptibility of isolates by the disc diffusion technique. Uropathogens were recovered from 137 (58.3%), with prevalence rates in Buea and Bamenda being 65.9% and 54% respectively. Predominant pathogens were Escherichia coli (31.4%), Klebsiella oxytoca (25.5%) and Staphylococcus spp (24.1%). Geographic variation in uropathogen distribution and antibiotic susceptibility was observed, and a significant difference in pathogen distribution with respect to gender. The 20–39 years age group had the highest prevalence of infection. All pathogens isolated were detected in this group. Isolates exhibited low susceptibility to antibiotics tested. Bamenda isolates generally exhibited lower susceptibility compared to those from Buea.

Conclusion

Regional variation in etiology of CAUTI and antibiotic susceptibility observed in our study emphasizes the need to establish local and national antimicrobial resistance monitoring systems in Cameroon to provide information for the development of CAUTI treatment guidelines.

Keywords:
Community-acquired urinary tract infection; Bacteria; Antibiotic susceptibility; Cameroon