Guava extracts neutralize leukotoxin-induced pro-inflammatory response, but not the bacteria-induced response. LDH-release (A &B) and IL-1β secretion (C &D) of human leukocytes exposed to A. actinomycetemcomitans leukotoxin (100 ng/ml) (A &C) or bacteria from the leukotoxin mutant strain D7SSΔltxA (10 bacteria/leukocyte) (B &D) for 60 min. Mean ± SD of 3 experiments is shown and significant leukotoxin neutralization is indicated (*).
Kwamin et al. BMC Research Notes 2012 5:203 doi:10.1186/1756-0500-5-203