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Open Access Research article

Differential expression of the angiogenesis growth factors in psoriasis vulgaris

Siaw-Cheok Liew1*, Esha Das-Gupta2, Srikumar Chakravarthi1, Shew-Fung Wong1, Nagarajah Lee3, Najeeb Safdar4 and Adawiyah Jamil5

Author Affiliations

1 Department of Postgraduate Studies and Research, International Medical University, Kuala Lumpur, Malaysia

2 Department of Internal Medicine, International Medical University, Seremban, Malaysia

3 Open University, Kuala Lumpur, Malaysia

4 Department of Dermatology, Tuanku Ja’afar Hospital, Seremban, Malaysia

5 Department of Dermatology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia

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BMC Research Notes 2012, 5:201  doi:10.1186/1756-0500-5-201

Published: 26 April 2012

Abstract

Background

Angiogenesis has been reported to be one of the contributory factors to the pathogenesis of psoriasis vulgaris. This study aims to compare the expression of different angiogenesis growth factors namely (1) the vascular endothelial growth factor (VEGF) subfamily: A, B, C, D and placenta growth factor (PlGF); (2) nerve growth factor (NGF) and (3) von Willebrand factor (vWFr) in the skins of patients with psoriasis vulgaris and non-psoriatic volunteers.

Results

Comparative immunohistochemistry study was performed on the paraffin-sectioned psoriatic and healthy skins with the abovementioned markers. VEGF-C (p = 0.016) and NGF (p = 0.027) were expressed intensely in the cases when compared with the controls. The NGF was the only marker that was solely expressed in the cases and absent in all the controls.

Conclusion

The NGF (angiogenesis) and VEGF-C (lymphangiogenesis) might play a crucial role in the pathogenesis of psoriasis vulgaris and could be researched further as potential new targeted therapies for psoriasis vulgaris.