Table 2

Comparison of various parameters in patients with mild (<33% of hepatocytes affected) or severe (>33% of hepatocytes affected) steatosis and those without steatosis (univariate analysis)

No steatosis

(n=82)

Steatosis

(n=102)

Mild steatosis

(n=76)

Severe steatosis

(n=26)

pa pb pc
Median age (IQR), yrs 40 (36-45) 41 (37-45) 41 (36-45) 41 (37-48) 0.38 0.66 0.81
Male gender, n (%) 66 (80) 88 (86) 67 (88) 21 (81) 0.32 0.39 0.34
IVDU, n (%) 50 (62) 77 (76) 54 (71) 23 (88) 0.05 0.03 0.11
Alcohol use, n (%) 29 (35) 38 (37) 29 (38) 9 (35) 0.88 0.92 0.82
Median duration of HIV (IQR), yrs 10 (5-14) 12 (8-14) 12 (8-15) 11 (7-13) 0.17 0.23 0.30
Median CD4 cell count (IQR), /mm3 346 (228-560) 308 (227-423) 305 (227-435) 313 (191-398) 0.10 0.24 0.67
HIV RNA<400 copies/ml, n (%) 58 (72) 61 (63) 46 (62) 15 (65) 0.26 0.45 1.0
HCV genotype 3, n (%) 13 (16) 34 (35) 18 (25) 16 (64) 0.005 <.0001 <.0001
Median HCV RNA (IQR), logIU/ml 5.97 (5.65-6.50) 6.30 (6.00-6.72) 6.22 (5.80-6.64) 6.69 (6.27-7.06) 0.003 0.0003 0.004
Median ALT (IQR), U/l 67 (40-119) 87 (54-130) 83 (51-121) 113 (84-132) 0.04 0.01 0.03
Median AST (IQR), U/l 56 (37-78) 77.5 (50-104) 70 (48-102) 78 (59-105) 0.001 0.003 0.33
Median alkaline phosphase (IQR), U/l 90 (70-115) 89 (69-112) 90 (72-113) 80 (65-95) 0.46 0.27 0.15
Median GGT (IQR), U/l 71 (41-139) 87 (43-196) 92 (44-198) 73 (30-180) 0.09 0.09 0.19
Median glycemia (IQR), mmol/l 4.80 (4.30-5.45) 4.92 (4.30-5.22) 4.80 (4.30-5.20) 4.90 (4.35-5.26) 0.79 0.96 0.97
Glycemia 5.6mmol/l, n (%) 16 (21) 17 (17) 12 (16) 5 (21) 0.56 0.77 0.76
Glycemia 7.0mmol/l, n (%) 1 (1) 6 (6) 6 (8) 0 (0) 0.14 0.08 0.33
Median total cholesterol (IQR), mmol/l 4.40 (3.73-5.33) 4.00 (3.30-4.79) 4.01 (3.30-5.03) 3.72 (3.06-4.37) 0.01 0.02 0.30
Median triglycerides (IQR), mmol/l 1.47 (0.97-2.08) 1.51 (0.99-2.20) 1.53 (1.04-2.24) 1.23 (0.90-1.74) 0.86 0.51 0.28
Triglycerides 1.7mmol/l, n (%) 30 (40) 30 (33) 23 (33) 7 (29) 0.33 0.56 0.80
Fibrosis F3-F4, n (%) 12 (15) 31 (30) 25 (33) 6 (23) 0.01 <0.001 1.0
Metavir score activity A2/A3, n (%) 21 (26) 34 (33 ) 29 (38 ) 5 (19 ) 0.28 0.11 0.09

pa Comparison of patients with versus without steatosis (Kruskal-Wallis test for quantitative variables, 2 test or Fisher's exact test for qualitative variables).

pb Comparison of patients with mild or severe steatosis versus without steatosis (Kruskal-Wallis test for quantitative variables, 2 test for qualitative variables).

pc Comparison of patients with mild versus severe steatosis (Kruskal-Wallis/Wilcoxon test for quantitative variables, 2 test or Fisher's exact test for qualitative variables).

Martinez et al.

Martinez et al. BMC Research Notes 2012 5:180   doi:10.1186/1756-0500-5-180

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