Open Access Research article

Susceptibility testing of Atopobium vaginae for dequalinium chloride

Guido Lopes dos Santos Santiago1*, Philipp Grob2, Hans Verstraelen3, Florian Waser2 and Mario Vaneechoutte1

Author Affiliations

1 Laboratory Bacteriology Research, Faculty Medicine & Health Sciences, University of Ghent, De Pintelaan 185, Ghent 9000, Belgium

2 Medinova AG, Eggbuehlstrasse 14, Zurich 8052, Switzerland

3 Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Ghent, Belgium

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BMC Research Notes 2012, 5:151  doi:10.1186/1756-0500-5-151

Published: 19 March 2012

Abstract

Background

Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum.

Methods

The MIC was determined with a broth microdilution assay.

Results

The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between < 0.0625 and 2 μg/ml.

Conclusions

This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole.